Institut national de la santé et de la recherche médicale (INSERM), Unité mixte de recherche (UMR) 1086 ANTICIPE, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France.
Institut national de la santé et de la recherche médicale (INSERM), Unité mixte de recherche (UMR) 1086 ANTICIPE, Caen, France; Centre de Lutte Contre le Cancer François Baclesse, Caen, France.
Cancer Epidemiol. 2022 Jun;78:102125. doi: 10.1016/j.canep.2022.102125. Epub 2022 Mar 15.
Specific farming types and tasks have rarely been studied in relation to colorectal cancer (CRC). We evaluated associations between 5 types of livestock and 13 types of crops in relation to CRC and its subsites within the Agriculture and Cancer (AGRICAN) study.
AGRICAN cohort includes 181,842 agricultural workers living in 11 French geographical areas. Data on farming types and tasks was collected by self-administered questionnaires. We identified 2 609 CRC, 972 right colon, 689 left colon and 898 rectal incident cancer cases during follow-up from 2005 to 2015. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).
Significantly increased CRC risk was observed for farmers producing horses (HR=1.18, 95% CI 1.06-1.31), sunflower (HR=1.23, 95% CI 1.03-1.45) and field vegetables (HR=1.18, 95% CI 1.02-1.36). Positive associations were also observed for pig, poultry and wheat/barley. Some associations were observed only for specific subsites: left colon cancer was associated with fruit growing (HR=1.36, 95% CI 1.09-1.70) and potato (HR=1.28, 95% CI 1.05-1.57). Tasks related to livestock (animal care, insecticide treatment, disinfection of milking equipment and building) or to crop (haymaking, sowing, pesticide treatment, seed treatment, harvesting) were also associated with CRC. Duration and size of farming types/task increased the risk for some of the associations. Analysis stratified by sex suggested an interaction with several farming types/task.
The current study showed original and positive findings for several farming types and tasks and CRC risk, overall and by subsites.
特定的农业类型和任务与结直肠癌（CRC）的关系鲜有研究。我们在农业与癌症（AGRICAN）研究中评估了 5 种牲畜和 13 种作物与 CRC 及其亚部位的相关性。
AGRICAN 队列包括居住在法国 11 个地理区域的 181842 名农业工人。通过自填式问卷收集农业类型和任务的数据。我们在 2005 年至 2015 年期间的随访中确定了 2609 例 CRC、972 例右结肠癌、689 例左结肠癌和 898 例直肠癌新发病例。使用 Cox 比例风险模型估计风险比（HR）和 95%置信区间（95%CI）。
从事种植马（HR=1.18，95%CI 1.06-1.31）、向日葵（HR=1.23，95%CI 1.03-1.45）和露天蔬菜（HR=1.18，95%CI 1.02-1.36）的农民 CRC 风险显著增加。猪、家禽和小麦/大麦也存在正相关。一些关联仅在特定的亚部位观察到：左结肠癌与水果种植（HR=1.36，95%CI 1.09-1.70）和土豆（HR=1.28，95%CI 1.05-1.57）有关。与牲畜（动物护理、杀虫剂处理、挤奶设备和建筑物的消毒）或作物（干草制作、播种、农药处理、种子处理、收获）相关的任务也与 CRC 相关。一些关联的风险随农业类型/任务的持续时间和规模的增加而增加。按性别分层的分析表明，这些关联与几种农业类型/任务存在交互作用。
本研究对几种农业类型和任务与 CRC 风险的相关性，包括总体和亚部位，得出了一些新颖和积极的发现。
