Department of Cardiology, Chongqing Fifth People's Hospital, No. 24 Renji Road, Chongqing, 400000, China.
Cell Commun Signal. 2022 Mar 18;20(1):33. doi: 10.1186/s12964-022-00829-z.
Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in non-excitable and excitable (i.e., skeletal and cardiac muscle) cells. These channels are triggered by Ca2+ depletion of the endoplasmic reticulum and sarcoplasmic reticulum, independently of inositol 1,4,5-trisphosphate (InsP3), which is involved in cell growth, differentiation, and gene transcription. When the Ca2+ store is depleted, stromal interaction molecule1 (STIM1) as Ca2+ sensor redistributes into discrete puncta near the plasma membrane and activates the protein Ca2+ release activated Ca2+ channel protein 1 (Orai1). Accumulating evidence suggests that SOC is associated with several physiological roles in endothelial dysfunction and vascular smooth muscle proliferation that contribute to the progression of cardiovascular disease. This review mainly elaborates on the contribution of SOC in the vasculature (endothelial cells and vascular smooth muscle cells). We will further retrospect the literature implicating a critical role for these proteins in cardiovascular disease. Video Abstract.
储存操作通道（SOC）是高度选择性的 Ca2+通道，可介导非兴奋性和兴奋性（即骨骼肌和心肌）细胞中的 Ca2+内流。这些通道由内质网和肌浆网的 Ca2+耗竭触发，与参与细胞生长、分化和基因转录的肌醇 1,4,5-三磷酸（InsP3）无关。当 Ca2+库耗尽时，基质相互作用分子 1（STIM1）作为 Ca2+传感器重新分布到靠近质膜的离散点状区域，并激活蛋白 Ca2+释放激活的 Ca2+通道蛋白 1（Orai1）。越来越多的证据表明，SOC 与内皮功能障碍和血管平滑肌增殖中的几种生理作用有关，这些作用有助于心血管疾病的进展。本综述主要阐述了 SOC 在血管（内皮细胞和血管平滑肌细胞）中的作用。我们将进一步回顾文献，这些文献表明这些蛋白质在心血管疾病中起着关键作用。视频摘要。
