High-Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Alderley Park, UK.
Drug Discov Today. 2022 Aug;27(8):2051-2056. doi: 10.1016/j.drudis.2022.03.010. Epub 2022 Mar 15.
Challenged by ageing infrastructure and increasingly demanding screening cascades, AstraZeneca High Throughput Screening department has developed advanced automation systems that can support both current needs and future strategies in drug discovery. Through collaboration with HighRes Biosolutions and other third-party vendors, highly versatile automated modular platforms have been designed. Safety features such as collaborative robots allow enhanced system accessibility, and adaptive scheduling software has improved protocol design and system recovery. These innovations have led to significant improvements in system flexibility while maintaining screening productivity.
老化的基础设施和日益增长的筛选级联给 AstraZeneca 高通量筛选部门带来了挑战，该部门已经开发出先进的自动化系统，可以支持药物发现领域当前的需求和未来的战略。通过与 HighRes Biosolutions 和其他第三方供应商的合作，设计了高度通用的自动化模块化平台。协作机器人等安全功能提高了系统的可访问性，自适应调度软件改进了方案设计和系统恢复。这些创新在保持筛选效率的同时，显著提高了系统的灵活性。
