Pathology, Isala, Department of Pathology, Zwolle, The Netherlands
Urology, Ziekenhuis Sint Jansdal, Harderwijk, Gelderland, The Netherlands.
BMJ Case Rep. 2022 Mar 18;15(3):e248498. doi: 10.1136/bcr-2021-248498.
Within the group of gonadal sex cord-stromal tumours, microcystic stromal tumour (MCST) is a rare entity. In the literature, most case series and reviews discussed MCST arising in the ovary, only one case-report concerned a testicular MCST. We present a Caucasian man in his late 30s, who presented with an MCST in his right testis. The tumour was encapsulated and composed of vaguely lobulated cellular nodules and cystic spaces with bland spindle cells and hyalinised fibrous stroma. By immunohistochemistry, the tumour cells expressed cluster designation 10, androgen receptor, steroidogenic factor-1 and nuclear beta-catenine, and there was focal nuclear expression of cyclin D1. Molecular diagnostics confirmed the presence of an exon 3 mutation (c.98C>T) in the gene. These features are similar to MSCT described in the ovary. Clinical follow-up (more than 1 year) was uneventful.Although the clinical and radiological presentation was that of a possible malignant testicular lesion, this entity is benign.
在性腺性索-间质肿瘤中，微囊性间质肿瘤（MCST）是一种罕见的实体瘤。在文献中，大多数病例系列和综述讨论了发生在卵巢的 MCST，只有一例报告涉及睾丸 MCST。我们报告了一位 30 多岁的白种人男性，他的右侧睾丸患有 MCST。肿瘤有包膜，由模糊的小叶状细胞结节和囊性空间组成，伴有温和的梭形细胞和玻璃样纤维化基质。通过免疫组织化学，肿瘤细胞表达簇分化 10、雄激素受体、类固醇生成因子 1 和核 β-连环蛋白，并且 cyclin D1 存在核表达焦点。分子诊断证实存在 基因外显子 3 突变（c.98C>T）。这些特征与卵巢中的 MSCT 相似。临床随访（超过 1 年）无异常。尽管临床和影像学表现可能是恶性睾丸病变，但该实体是良性的。
