Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, School of Medicine & Public Health, University of Wisconsin, UW Carbone Cancer Center, Madison, WI, USA.
Department of Pathology, School of Medicine & Public Health, University of Wisconsin, Madison, WI, USA.
Childs Nerv Syst. 2022 Oct;38(10):2021-2024. doi: 10.1007/s00381-022-05500-z. Epub 2022 Mar 18.
Juvenile xanthogranuloma is a type of non-Langerhans cell histiocytic process that appears primarily in children and is described as a benign lesion. Although they typically present as a cutaneous lesion, it can also present in other areas including within the central nervous system. We report a 6-month-old infant who presented with seizure-like activity who was found to have a single intracranial mass within the right temporal area on magnetic resonance imaging of the head. The mass was biopsied and pathologically identified as a juvenile xanthogranuloma. In order to avoid the morbidity associated with a gross total resection, an intralesional steroid injection was utilized for treatment which our patient tolerated well. Intralesional steroid injection for the treatment of a symptomatic isolated intracranial juvenile xanthogranuloma has not been described but was successful for our patient.
幼年黄色肉芽肿是一种非朗格汉斯细胞组织细胞增生症，主要发生在儿童，被描述为良性病变。尽管它们通常表现为皮肤损伤，但也可能出现在其他部位，包括中枢神经系统。我们报告了一例 6 个月大的婴儿，因癫痫样发作就诊，头部磁共振成像显示右侧颞区有单个颅内肿块。该肿块进行了活检，并通过病理诊断为幼年黄色肉芽肿。为了避免因广泛全切除而引起的发病率，我们对患者采用了病变内类固醇注射治疗，患者对此治疗耐受良好。然而，针对症状性孤立性颅内幼年黄色肉芽肿，病变内类固醇注射治疗尚未被描述，但对我们的患者是有效的。
