Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, F-59000, Lille, France.
Analytical Chemistry Department, School of Chemistry, College of Science, University of Tehran, 1417935840, Tehran, Iran.
Mikrochim Acta. 2022 Mar 18;189(4):150. doi: 10.1007/s00604-022-05181-0.
This study investigated, for the first time, the antimicrobial properties of polyethylene glycol-functionalized poly(N-phenylglycine) nanoparticles (PNPG-PEG NPs). PNPG-PEG NPs exhibit high extinction coefficient in the near-infrared (NIR) region; they can convert light energy into heat energy with high thermal transformation efficiency. Additionally, they can generate cytotoxic reactive oxygen species (ROS) upon light irradiation. Also, PNPG-PEG NPs are not cytotoxic. All these properties make them appropriate for combined dual-modal photothermal and photodynamic therapies. The antibacterial activity of PNPG-PEG NPs was assessed using Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) pathogenic strains. The results revealed that NIR light (810 nm) irradiation for 10 min could kill effectively the planktonic bacteria and destroy Escherichia coli and Staphylococcus aureus biofilms. The results demonstrated that PNPG-PEG NPs represent a very effective nanoplatform for killing of pathogenic bacteria.
这项研究首次考察了聚乙二醇功能化聚（N-苯甘氨酸）纳米粒子（PNPG-PEG NPs）的抗菌性能。PNPG-PEG NPs 在近红外（NIR）区域具有高消光系数；它们可以将光能高效转化为热能。此外，它们在光照下还能产生细胞毒性活性氧（ROS）。而且，PNPG-PEG NPs 无细胞毒性。所有这些特性使它们适合联合双模光热和光动力疗法。采用大肠杆菌（革兰氏阴性）和金黄色葡萄球菌（革兰氏阳性）致病菌株评估了 PNPG-PEG NPs 的抗菌活性。结果表明，近红外光（810nm）照射 10 分钟即可有效杀灭浮游菌，并破坏大肠杆菌和金黄色葡萄球菌生物膜。结果表明，PNPG-PEG NPs 是一种非常有效的杀灭致病菌的纳米平台。
