Medical Sciences University, Izmir Tepecik Hospital, Izmir, Turkey.
Medical Sciences University, Izmir Bozyaka Hospital, Izmir, Turkey.
Acta Gastroenterol Belg. 2022 Jan-Mar;85(1):35-45. doi: 10.51821/85.1.7352.
The prognostic value of H. pylori, which infects more than half of the human population living in the world and plays a role in gastric cancer pathogenesis, is controversial. Our aim is to investigate the relationship between H. pylori and prognostic factors in gastric cancer.
The data of 110 patients (38 females and 72 males) that underwent surgeries due to gastric cancer between 2014 and 2017 were retrospectively analyzed. The relationships between survival (disease-free and overall) and factors such as p53, HER2/neu, Ki-67, neutrophil and platelet lymphocyte ratio (NLR / PLR), histopathological and demographic characteristics were examined. In addition, the results of H. pylori positive and negative groups were compared.
Sixty-one (55%) patients were H. pylori negative and 49 (45%) were positive. In multivariate analysis, TNM stage, lymph node capsule invasion and NLR were determined as independent prognostic factors in both disease-free and overall survival. Age>62 and PLR>14.3 were determined as independent predictive factors of poor prognosis in overall survival. In univariate analysis, tumor diameter of >4.3 cm, lymphovascular and perineural invasion, and diffuse p53 expression were determined as predictive factors of poor prognosis in disease-free and overall survival. The effectiveness of these markers in prognosis was not different between H. pylori negative and positive groups.
While age, tumor diameter, TNM stage, lymph node capsule invasion, perineural and lymphovascular invasion, diffuse p53, PLR, and NLR were determined as prognostic factors in gastric cancer, these factors were not affected by the presence of H. pylori.
感染了世界上一半以上人口并在胃癌发病机制中起作用的 H. pylori 的预后价值存在争议。我们的目的是研究 H. pylori 与胃癌预后因素之间的关系。
回顾性分析了 2014 年至 2017 年间因胃癌接受手术的 110 名患者（38 名女性和 72 名男性）的数据。检查了生存（无病和总生存）与 p53、HER2/neu、Ki-67、中性粒细胞和血小板淋巴细胞比（NLR / PLR）、组织病理学和人口统计学特征等因素之间的关系。此外，还比较了 H. pylori 阳性和阴性组的结果。
61 名（55%）患者 H. pylori 阴性，49 名（45%）阳性。多变量分析显示，TNM 分期、淋巴结包膜侵犯和 NLR 是无病和总生存的独立预后因素。年龄>62 岁和 PLR>14.3 是总生存不良预后的独立预测因素。在单因素分析中，>4.3cm 的肿瘤直径、血管淋巴管和神经周围侵犯以及弥漫性 p53 表达被确定为无病和总生存不良预后的预测因素。这些标志物在预后中的有效性在 H. pylori 阴性和阳性组之间没有差异。
虽然年龄、肿瘤直径、TNM 分期、淋巴结包膜侵犯、神经周围和血管淋巴管侵犯、弥漫性 p53、PLR 和 NLR 被确定为胃癌的预后因素，但这些因素不受 H. pylori 的影响。
