经内镜黏膜下剥离术治疗高级别肛门上皮内瘤变：一例报告。
High-grade anal intraepithelial neoplasia treated with endoscopic submucosal dissection: a case report.
机构信息
Gastroenterology Department, Centro Hospitalar de São João, Porto, Portugal.
Pathology Department, Centro Hospitalar de São João, Porto, Portugal.
出版信息
Acta Gastroenterol Belg. 2022 Jan-Mar;85(1):108-110. doi: 10.51821/85.1.8192.
Anal intraepithelial neoplasia is a premalignant lesion for anal squamous cell carcinoma. Current treatment options, consisting of topical therapy and local ablative procedures with electrocautery or radiofrequency ablation, are effective although recurrence rates are high. Experience with endoscopic submucosal dissection for anal lesions is limited, with only a few cases of anal intraepithelial neoplasia and early anal squamous cell carcinoma. We present a 65-year-old woman with high-grade anal intraepithelial neoplasia successfully removed by endoscopic submucosal dissection with no complications or signs of recurrence after 5 months, suggesting that this technique could be a safe and effective approach for management of anal premalignant lesions.
肛门上皮内瘤变是肛门鳞状细胞癌的癌前病变。目前的治疗选择包括局部治疗和电灼或射频消融等局部消融治疗，尽管复发率较高，但这些方法是有效的。内镜黏膜下剥离术治疗肛门病变的经验有限，仅有少数肛门上皮内瘤变和早期肛门鳞状细胞癌的病例。我们报告了一例 65 岁女性，成功地通过内镜黏膜下剥离术切除了高级别肛门上皮内瘤变，术后 5 个月无并发症或复发迹象，提示该技术可能是一种安全有效的治疗肛门癌前病变的方法。
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