Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
China Institute of Atomic Energy, Beijing 102413, China.
Nucl Med Biol. 2022 May-Jun;108-109:54-60. doi: 10.1016/j.nucmedbio.2022.03.001. Epub 2022 Mar 10.
Yttrium-86 (Y, t = 14.7 h, 33% β) is a nonstandard medical nuclide with a longer half-life than other standard nuclides such as gallium-68 for radiolabelling for PET (positron emission computed tomography) imaging. Y is compatible with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and can be used to evaluate DOTA-chelated radiopharmaceuticals with long clearance half-lives, particularly therapeutic radiopharmaceuticals in several days. Y can be produced through Sr(p, n)Y reaction, in which Sr-enriched SrCO powder is bombarded with low-energy protons. To handle the SrCO powder, a powder target for Y production in 14.6 MeV proton cyclotron was designed while maximizing yield, reliability and efficiency. To that end, the target's primary design parameters were traversed, simulated and optimized using computer algorithms to obtain advantageous parameter combinations. In this way, Y was produced on the powder target with high yield and successfully isolated with high purity (>97%) by solid-phase extraction via DGA resin for high-quality PET imaging and drug screening.
钇-86（Y，t=14.7h，33%β）是一种非标准的医用核素，其半衰期比其他标准核素如镓-68更长，可用于放射性标记正电子发射断层扫描（PET）成像。Y 与 DOTA（1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸）兼容，可用于评估具有长清除半衰期的 DOTA 螯合放射性药物，特别是在数天内的治疗性放射性药物。Y 可以通过 Sr(p, n)Y 反应来生产，其中 Sr 富集的 SrCO 粉末被低能质子轰击。为了处理 SrCO 粉末，设计了用于 14.6MeV 质子回旋加速器中 Y 生产的粉末靶，同时最大限度地提高产量、可靠性和效率。为此，使用计算机算法遍历、模拟和优化了靶的主要设计参数，以获得有利的参数组合。通过这种方式，在粉末靶上以高产率生产了 Y，并通过 DGA 树脂固相萃取以高纯度（>97%）成功分离，用于高质量的 PET 成像和药物筛选。
