Efremidis A P, Sabato U, Taff I, Krieger H, Bekesi J G
Clin Neurol Neurosurg. 1986;88(2):101-7. doi: 10.1016/s0303-8467(86)80004-x.
We describe the use of a panel of monoclonal antibodies, directed against leukocyte surface antigens to characterize CSF mononuclear cells with regard to malignancy when cytopathology was inconclusive. Cytocentrifuged preparations from three patients in which traditional modalities had not yielded a diagnosis were studied, utilizing a panel of antibodies for B and T cell antigens. All three patients were found to have B cell lymphoma of the CNS. Rapid institution of the appropriate therapy resulted in marked improvement of CNS symptoms in each case. Our results indicate that in patients with CNS disease and CSF pleocytosis of undefined nature, this technique may provide rapid and precise diagnostic information.
我们描述了一组针对白细胞表面抗原的单克隆抗体的应用，当细胞病理学诊断不明确时，用于鉴定脑脊液单核细胞是否存在恶性病变。利用一组针对B细胞和T细胞抗原的抗体，对3例采用传统方法未能确诊的患者的细胞离心涂片进行了研究。结果发现，所有3例患者均患有中枢神经系统B细胞淋巴瘤。迅速采取适当治疗后，每位患者的中枢神经系统症状均有显著改善。我们的结果表明，对于患有中枢神经系统疾病且脑脊液细胞增多性质不明的患者，该技术可提供快速且准确的诊断信息。
