Psychological Sciences Research Institute, Université catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.
European Institute for ORL-HNS, Department of Otorhinolaryngology and Head & Neck Surgery, Antwerp, Belgium; Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium; Faculty of Education, Health and Social Work, University College Ghent, Gent, Belgium; Phonanium, Lokeren, Belgium.
J Voice. 2024 Jul;38(4):969.e5-969.e19. doi: 10.1016/j.jvoice.2022.02.008. Epub 2022 Mar 16.
This review of the methodology and results of studies involving a sustained vowel phonation task during functional Magnetic Resonance Imaging (fMRI) aims to contribute to the identification of brain regions involved in phonation for healthy subjects.
This review was performed using the PubMed electronic database.
A review was conducted, according to PRISMA guidelines, between September and November 2020, using the following search term pairs: "fMRI and Phonation" and "fMRI and Voice." Activation likelihood estimation analysis was performed. A qualitative analysis was also performed to specify the frequency of activation of each region, as well as the various activation clusters within a single region.
Seven studies were included and analyzed. Five of the seven studies were selected for the activation likelihood estimation meta-analysis which revealed significant convergent activation for only one cluster located in the left precentral gyrus (BA4). A qualitative review provides an overview of brain activation. Primary motor and premotor areas were the only activated areas in all studies included. Other regions previously considered to be implicated in phonation were often activated in sustained vowel phonation tasks. Additionally, areas generally associated with articulation or language also showed activation.
Methodological recommendations are suggested to isolate the phonatory component and reduce variability between future studies. Based on the qualitative analysis, this review does not support a distinction between regions more related to phonation and regions more related to articulation. Further research is required seeking to isolate the vocal component and to improve insight into human brain network involved in phonation.
本综述回顾了涉及功能磁共振成像（fMRI）中持续元音发声任务的研究方法和结果，旨在帮助确定健康受试者发声所涉及的脑区。
本综述使用 PubMed 电子数据库进行。
根据 PRISMA 指南，于 2020 年 9 月至 11 月进行了综述，使用了以下搜索词对：“fMRI 和发声”和“fMRI 和语音”。进行了激活似然估计分析。还进行了定性分析，以指定每个区域的激活频率，以及单个区域内的各种激活簇。
共纳入 7 项研究进行分析。其中 5 项研究被选入激活似然估计荟萃分析，仅发现一个位于左中央前回（BA4）的显著聚集激活。定性综述提供了脑激活的概述。在所有纳入的研究中，初级运动和前运动区是唯一激活的区域。其他以前被认为与发声有关的区域在持续元音发声任务中经常被激活。此外，通常与发音或语言相关的区域也显示出激活。
建议提出方法学建议，以分离发声成分并减少未来研究之间的变异性。基于定性分析，本综述不支持将与发声更相关的区域与与发音更相关的区域区分开来。需要进一步研究，以分离发声成分并深入了解参与发声的人类大脑网络。
