Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China.
International Medical Services, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
Prim Care Diabetes. 2022 Jun;16(3):457-465. doi: 10.1016/j.pcd.2022.03.003. Epub 2022 Mar 16.
Our study aimed to assess the existing evidence on whether serum uric acid (SUA) levels are associated with diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
We conducted a systematic search of articles up to October 2021 in Medline, Embase, The Cochrane Library and Web of Science that estimated DKD by SUA levels in patients with T2DM. Pooled relative risks with 95% CI were calculated using random effects models RESULTS: A total of eight cohort studies involving 25,741 T2DM patients were included. Meta-analysis showed that compared the highest with the lowest category of SUA level, the summary risk ratios were 2.04 (95%CI 1.43-2.92, P < 0.001). The linear dose-response analysis revealed that the risk of DKD increased by 24% for each 1 mg/dl increase of SUA. The non-linear dose-response analysis also showed a significant relevance between SUA and the risk of DKD in patients with type 2 diabetes mellitus (P < 0.001).
Serum uric acid is associated with an increased risk of diabetic kidney disease in patients with type 2 diabetes mellitus. Serum uric acid level could be a good indicator for predicting diabetic kidney disease in patients with type 2 diabetes mellitus.
本研究旨在评估血清尿酸（SUA）水平与 2 型糖尿病（T2DM）患者糖尿病肾病（DKD）之间是否存在关联的现有证据。
我们对截至 2021 年 10 月在 Medline、Embase、The Cochrane Library 和 Web of Science 中评估 T2DM 患者通过 SUA 水平诊断 DKD 的文章进行了系统检索。使用随机效应模型计算汇总相对风险及其 95%置信区间。
共纳入 8 项队列研究，涉及 25741 例 T2DM 患者。Meta 分析显示，与 SUA 水平最低组相比，最高组的汇总风险比为 2.04（95%CI 1.43-2.92，P<0.001）。线性剂量-反应分析表明，SUA 每增加 1mg/dl，DKD 的风险增加 24%。非线性剂量-反应分析也表明，SUA 与 2 型糖尿病患者 DKD 的风险之间存在显著相关性（P<0.001）。
血清尿酸与 2 型糖尿病患者的糖尿病肾病风险增加有关。血清尿酸水平可能是预测 2 型糖尿病患者糖尿病肾病的良好指标。
