Institute of Metrology, 10200, Havana, Cuba.
Institute of Cybernetics, Mathematics and Physics, 10400, Havana, Cuba.
Sci Rep. 2022 Mar 19;12(1):4748. doi: 10.1038/s41598-022-08502-8.
A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a set of genes. The risk of cancer in a tissue is estimated as the microstate probability to transit from the normal to the tumor region in gene expression space. The formula coming from the contribution of large Levy jumps seems to provide a qualitatively correct description of the lifetime risk of cancer in 8 tissues, and reveals an interesting connection between the risk and the way the tissue is protected against infections.
组织的一小部分定义了基因表达空间中的微观状态。突变、表观遗传事件或外部因素导致微观状态位移，这些位移通过结合小的独立基因表达变化和大的 Levy 跳跃来建模，这些跳跃是由一组基因的集体变化引起的。组织中癌症的风险估计为基因表达空间中从正常状态到肿瘤区域的微观状态概率。来自大 Levy 跳跃贡献的公式似乎为 8 种组织中的癌症终生风险提供了定性上正确的描述，并揭示了风险与组织抵御感染的方式之间的有趣联系。
