正常体细胞突变与癌症转化。
Normal Somatic Mutations in Cancer Transformation.
机构信息
Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK; Department of Medical and Molecular Genetics, King's College London, London WC2R 2LS, UK.
出版信息
Cancer Cell. 2021 Feb 8;39(2):125-129. doi: 10.1016/j.ccell.2020.11.002. Epub 2020 Nov 20.
Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.
基因改变在推动癌症的发生和发展中起着重要作用。然而，在肿瘤发生之前正常细胞中发生的遗传事件仍然未知。最近的研究已经开始对正常人体组织中的体细胞突变进行定位，在这里我们讨论它们对我们理解肿瘤发生的意义。
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