Kurtgil Mehmet Emre, Kocyigit Burhan Fatih, Berk Ejder, Koca Tuba Tulay, Akyol Ahmet, Nacitarhan Vedat
Department of Physical Medicine and Rehabilitation, 25 Aralık State Hospital, Gaziantep, Turkey.
Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey.
Rheumatol Int. 2022 May;42(5):853-859. doi: 10.1007/s00296-022-05107-2. Epub 2022 Mar 20.
Fibromyalgia syndrome (FMS) has previously been linked to cognitive dysfunction. The aim of this study was to compare visual reaction time (RT) between FMS patients and healthy subjects. The relationship was examined between RT and clinical parameters in FMS patients, and it was aimed to evaluate the effect of drugs used in the treatment of FMS on RT. A total of 112 FMS patients and 110 healthy volunteers were included in this cross-sectional research. Cognitive performance was evaluated with visual RT measurements. FMS patients were assessed using the Fibromyalgia impact questionnaire (FIQ), Beck Depression Inventory (BDI), Fatigue Severity Scale (FSS) and Pittsburgh Sleep Quality Index (PSQI). The drugs used in the treatment of FMS were recorded. Significantly prolonged visual RT measurements were detected in FMS patients (p < 0.001). There was no significant difference in RT measurements between the patients who did not use drugs and those who were treated with serotonin noradrenaline reuptake inhibitor, gabapentinoid and combination therapy (p > 0.05). RT was significantly correlated with FIQ, BDI and PSQI scores in FMS patients (rho: 0.290, p = 0.002 for FIQ; rho: 0.253, p = 0.007 for BDI and rho: 0.312, p = 0.001 for PSQI). No significant correlation was detected between RT scores and FSS values (p > 0.05). Visual RT measurements were seen to be deteriorated in FMS patients. As the disease severity, depression level, and sleep disturbance increased, so the impairment in visual RT values became more prominent. The drugs used in the FMS treatment did not influence the RT scores. Cognitive performance tests should be incorporated in the physical examination and follow-up courses of FMS patients.
纤维肌痛综合征（FMS）此前已被认为与认知功能障碍有关。本研究的目的是比较FMS患者与健康受试者之间的视觉反应时间（RT）。研究了FMS患者的RT与临床参数之间的关系，并旨在评估用于治疗FMS的药物对RT的影响。这项横断面研究共纳入了112例FMS患者和110名健康志愿者。通过视觉RT测量评估认知表现。使用纤维肌痛影响问卷（FIQ）、贝克抑郁量表（BDI）、疲劳严重程度量表（FSS）和匹兹堡睡眠质量指数（PSQI）对FMS患者进行评估。记录用于治疗FMS的药物。在FMS患者中检测到视觉RT测量值显著延长（p < 0.001）。未使用药物的患者与接受5-羟色胺去甲肾上腺素再摄取抑制剂、加巴喷丁类药物和联合治疗的患者之间的RT测量值无显著差异（p > 0.05）。FMS患者的RT与FIQ、BDI和PSQI评分显著相关（FIQ：rho = 0.290，p = 0.002；BDI：rho = 0.253，p = 0.007；PSQI：rho = 0.312，p = 0.001）。RT评分与FSS值之间未检测到显著相关性（p > 0.05）。FMS患者的视觉RT测量值出现恶化。随着疾病严重程度、抑郁水平和睡眠障碍的增加，视觉RT值的损害变得更加明显。用于FMS治疗的药物未影响RT评分。认知表现测试应纳入FMS患者的体格检查和随访过程中。
