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甘氨脱氧胆酸在豚尾猕猴诱发急性胰腺炎中的作用。

Role of glycodeoxycholic acid to induce acute pancreatitis in Macaca nemestrina.

作者信息

Fauzi Achmad, Simadibrata Marcellus, Rani Abdul Azis, Sajuthi Dondin, Amanda Rosvitha, Makmun Dadang

机构信息

Gastroenterology-pancreatobiliarry and GI Endoscopy Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Tropical medicine Division Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

出版信息

J Med Primatol. 2022 Jun;51(3):134-142. doi: 10.1111/jmp.12577. Epub 2022 Mar 20.

DOI:10.1111/jmp.12577
PMID:35306662
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9310849/
Abstract

BACKGROUND

Acute pancreatitis exhibits a rapid clinical progression which makes it difficult to observe in human; hence, an experimental animal model is needed. This preliminary study performed an induction of acute pancreatitis using glycodeoxycholic acid (GDOC) in an experimental macaque model.

METHODS

GDOC injections (initial dose of 11.20 mg/kg) were administered in an escalating manner at specific time points. The injection was given along the bilio-pancreatic duct, followed by measurement of vital signs, serum amylase-lipase, TNF-α, procalcitonin, oxidative stress parameters, and microscopic and macroscopic findings.

RESULTS

The results indicated that acute pancreatitis occurred following induction with low-dose GDOC. Serum amylase and lipase levels increased with subsequent GDOC injections. Blood pressure and heart rate were elevated, indicating abdominal pain. Changes in TNF-α, procalcitonin, and oxidative stress values showed active inflammation. We observed histologic features of pancreatitis and as the dose increased, vasodilation of the splanchnic vasculatures was observed.

CONCLUSIONS

Small dose GDOC injection in the bilio-pancreatic duct may have a role to induce acute pancreatitis in Macaca nemestrina.

摘要

背景

急性胰腺炎临床进展迅速，难以在人体中进行观察；因此，需要建立实验动物模型。本初步研究在实验猕猴模型中使用甘氨脱氧胆酸（GDOC）诱导急性胰腺炎。

方法

在特定时间点以递增方式给予GDOC注射（初始剂量为11.20mg/kg）。沿胆胰管进行注射，随后测量生命体征、血清淀粉酶-脂肪酶、TNF-α、降钙素原、氧化应激参数以及微观和宏观检查结果。

结果

结果表明，低剂量GDOC诱导后发生了急性胰腺炎。随着后续GDOC注射，血清淀粉酶和脂肪酶水平升高。血压和心率升高，提示腹痛。TNF-α、降钙素原和氧化应激值的变化表明存在活动性炎症。我们观察到了胰腺炎的组织学特征，并且随着剂量增加，观察到内脏血管舒张。

结论

在胆胰管内注射小剂量GDOC可能在诱导豚尾猕猴发生急性胰腺炎中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/96e2d06b99c1/JMP-51-134-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/cf5d08207a25/JMP-51-134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/db82a5028fd0/JMP-51-134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/7dd5841df4c1/JMP-51-134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/e1b568c386c0/JMP-51-134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/96e2d06b99c1/JMP-51-134-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/cf5d08207a25/JMP-51-134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/db82a5028fd0/JMP-51-134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/7dd5841df4c1/JMP-51-134-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6353/9310849/96e2d06b99c1/JMP-51-134-g005.jpg

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Lipase or amylase for the diagnosis of acute pancreatitis?脂肪酶还是淀粉酶用于诊断急性胰腺炎？
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