Burckart G J, Canafax D M, Yee G C
Drug Intell Clin Pharm. 1986 Sep;20(9):649-52. doi: 10.1177/106002808602000901.
Cyclosporine is an important immunosuppressive agent in organ and bone marrow transplantation. The pharmacokinetics of cyclosporine are quite complex and are complicated by the availability of two assay systems that yield differing results. This article summarizes the views from two major solid organ transplant centers and one bone marrow transplant center on important cyclosporine monitoring questions. A general consensus exists in the four areas discussed that: cyclosporine concentrations must be monitored due in part to the extreme variability in kinetics, either blood or plasma can be used in monitoring programs, the radioimmunoassay or high pressure liquid chromatography can be used in routine monitoring, and the interpretation of cyclosporine concentrations must be performed in relation to patient variables that affect drug response and toxicity.
环孢素是器官和骨髓移植中一种重要的免疫抑制剂。环孢素的药代动力学相当复杂，且因两种检测系统的可用性而变得更加复杂，这两种检测系统会产生不同的结果。本文总结了两个主要实体器官移植中心和一个骨髓移植中心对环孢素重要监测问题的观点。在讨论的四个领域中存在一个普遍共识，即：由于动力学存在极大变异性，必须监测环孢素浓度；血液或血浆均可用于监测程序；放射免疫测定法或高压液相色谱法可用于常规监测；环孢素浓度的解释必须结合影响药物反应和毒性的患者变量进行。
