Cancer epidemiology program, center for immunization and infection research in cancer, 25301H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Palila Software, Reno, NV, USA.
Int J STD AIDS. 2022 Apr;33(5):462-466. doi: 10.1177/09564624221074468. Epub 2022 Mar 19.
This study aimed to compare COVID-19 positivity by HIV status and race/ethnicity using data from the U.S. National COVID Cohort Collaborative (N3C).
The N3C cohort (≥ 18 years) includes patients with any encounter after 1/1/2020 with SARS-CoV-2 laboratory tests. Detailed electronic medical records are centralized and harmonized across health-care organizations (34 sites). COVID-19 diagnosis was defined by RT-PCR or antibody testing. HIV infection was defined by standard diagnostic codes within 2 years prior to COVID-19 testing. Descriptive statistics and multivariable logistic regression were utilized to compare COVID-19 positivity and HIV status by patient's race/ethnicity.
Over 2.1 million patients were captured in the N3C as of 01/29/2021, of whom 372,716 (15%) were positive for COVID-19; 17,820 (0.7%) were PLWH of whom 2428 (13.6%) tested positive for COVID-19. COVID-19 positive PLWH were more likely to be 30+ years of age (90% vs. 70%; χ2 < 0.001), male (67% vs. 46%, χ2 < 0.001), and Black (44% vs. 15%, χ2 < 0.001) compared to HIV-negative patients. Compared to non-Hispanic/Latinx (NH)-White PLWH, NH-Black (aOR: 1.59, 95% CI: 1.37-1.86), Latinx (aOR: 2.17, 95% CI: 1.68-2.83), and NH-Asian (aOR: 2.18, 95% CI: 1.30-3.63) PLWH were more likely to have COVID-19 after adjustment for age, sex, and CharlsonDeyo comorbidity score.
PLWH and minoritized communities, including NH-Black and Latinx or Hispanic adults, appear to be disproportionately impacted by the COVID-19 pandemic.
本研究旨在利用美国国家 COVID 队列协作（N3C）的数据比较 HIV 状态和种族/民族对 COVID-19 阳性率的影响。
N3C 队列（≥18 岁）包括 2020 年 1 月 1 日以后有 SARS-CoV-2 实验室检测结果的患者。详细的电子病历在医疗机构之间集中并协调（34 个地点）。COVID-19 诊断通过 RT-PCR 或抗体检测确定。HIV 感染通过 COVID-19 检测前 2 年内的标准诊断代码确定。利用描述性统计和多变量逻辑回归比较 COVID-19 阳性率和患者的种族/民族与 HIV 状态的关系。
截至 2021 年 1 月 29 日，N3C 中收录了超过 210 万名患者，其中 372716 名（15%）COVID-19 检测阳性；17820 名（0.7%）为 PLWH，其中 2428 名（13.6%）COVID-19 检测阳性。COVID-19 阳性的 PLWH 更可能在 30 岁以上（90% vs. 70%；χ2<0.001）、男性（67% vs. 46%，χ2<0.001）和黑人（44% vs. 15%，χ2<0.001），与 HIV 阴性患者相比。与非西班牙裔/拉丁裔（NH）白人 PLWH 相比，NH 黑人（aOR：1.59，95%CI：1.37-1.86）、拉丁裔（aOR：2.17，95%CI：1.68-2.83）和 NH 亚裔（aOR：2.18，95%CI：1.30-3.63）PLWH 调整年龄、性别和 CharlsonDeyo 合并症评分后更易发生 COVID-19。
PLWH 和少数族裔群体，包括 NH 黑人以及拉丁裔或西班牙裔成年人，似乎受到 COVID-19 大流行的不成比例影响。
