Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Expert Rev Anti Infect Ther. 2022 Jul;20(7):1015-1023. doi: 10.1080/14787210.2022.2056019. Epub 2022 Mar 28.
(), a non-tuberculous mycobacterium (NTM), rare causes infection including localized pulmonary to disseminated disease in immunocompromised patients. An optimal pharmacological management practice has not yet been defined for this infection. This study investigates drug regimens and treatment outcomes in patients with M. simiae to describe different drug regimen with the therapeutic response.
The three databases PubMed, Scopus, and Web of science were systematically searched from June 1994 to June 2021 to retrieve relevant articles. The inclusion criterion included studies, which reported treatment outcomes in patients with infections. Treatment success was defined as the achievement of culture conversion, and the improvement of the symptoms and radiologic signs among the patients.
Data of 223 patients were retrieved from 40 studies. Duration of the treatment regimens used in different studies ranged from 2 to 12 months. The most common treatment regimens administered for infection were as follows: clarithromycin, rifampin, ethambutol, moxifloxacin, or ciprofloxacin and amikacin plus cotrimoxazole or pyrazinamide in some regimens. Macrolides, such as clarithromycin, combined with quinolones (such as moxifloxacin) and TMP/SMX, which are used in combination, had the most significant effect on eliminating the pulmonary signs of .
（），一种非结核分枝杆菌（NTM），在免疫功能低下的患者中罕见引起感染，包括局部肺部到播散性疾病。对于这种感染，尚未确定最佳的药物治疗方案。本研究调查了分枝杆菌感染患者的药物治疗方案和治疗结果，以描述不同药物方案的治疗反应。
从 1994 年 6 月至 2021 年 6 月，我们系统地在 PubMed、Scopus 和 Web of Science 这三个数据库中进行了检索，以获取相关文章。纳入标准包括报告分枝杆菌感染患者治疗结果的研究。治疗成功定义为培养物转换的实现，以及患者症状和影像学征象的改善。
从 40 项研究中检索到 223 名患者的数据。不同研究中使用的治疗方案持续时间从 2 个月到 12 个月不等。治疗分枝杆菌感染最常用的方案如下：克拉霉素、利福平、乙胺丁醇、莫西沙星或环丙沙星和阿米卡星加复方磺胺甲噁唑或吡嗪酰胺。大环内酯类药物如克拉霉素与喹诺酮类药物（如莫西沙星）联合使用，以及 TMP/SMX 联合使用，对消除肺部有最显著的效果。
