诊断与接种新型冠状病毒2型疫苗相关的菱形脑炎需要进行全面检查并排除各种鉴别诊断。
Diagnosing SARS-CoV-2 vaccination associated rhombencephalitis requires comprehensive work-up and exclusion of differentials.
作者信息
Finsterer Josef, Scorza Fulvio A, Scorza Carla A, Fiorini Ana C
机构信息
Neurology and Neurophysiology Center, Postfach 20, 1180, Vienna, Austria.
Disciplina de Neurociência, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São Paulo, Brazil.
出版信息
Neurol Res Pract. 2022 Mar 21;4(1):10. doi: 10.1186/s42466-022-00178-9.
In this letter we raise several concerns regarding the interesting article by Walter and Krämer about rhomb-encephalitis as a complication two months after the vaccination with an mRNA-based SARS-CoV_2 vaccine. The causal link between the vaccination and encephalitis remained unproven, a SARS-CoV-2 infection, Bickerstaff encephalitis were not excluded, the MRI rather suggests brainstem-encephlaitis than pure rhomb-encephalitis, and the cerebro-spinal fluid was not investigated for cytokines or glial markers. Neurologists are called to make all available effort to convincingly evaluate the etiology and the pathophysiological background of an undetermined condition.
在这封信中，我们对沃尔特和克雷默撰写的关于接种基于mRNA的SARS-CoV-2疫苗两个月后出现的菱形脑炎并发症的有趣文章提出了几点关切。疫苗接种与脑炎之间的因果关系尚未得到证实，未排除SARS-CoV-2感染、比克斯特法夫脑炎，MRI结果更提示为脑干脑炎而非单纯的菱形脑炎，且未对脑脊液进行细胞因子或神经胶质标志物检测。呼吁神经科医生尽一切努力令人信服地评估一种未明确病症的病因和病理生理背景。
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