Ellen & Martin Prosserman Centre for Neuromuscular Diseases University Health Network, University of Toronto, Canada.
Division of Endocrinology, Department of Medicine, Leadership Sinai Centre for Diabetes, Sinai Health System, University of Toronto, Toronto, Canada; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.
J Diabetes Complications. 2022 May;36(5):108169. doi: 10.1016/j.jdiacomp.2022.108169. Epub 2022 Mar 15.
To determine the prevalence and the associated clinical characteristics of orthostatic hypotension and orthostatic hypertension in patients with diabetic sensorimotor polyneuropathy (DSP).
A single-center retrospective cross-sectional study was conducted on 200 DSP patients who had 3-minute orthostatic measures as part of the standard clinic evaluation. We measured the heart rate (HR) and blood pressure (BP) supine and again after 3 min of standing.
The prevalence of orthostatic hypotension was 19.5% and that of orthostatic hypertension was 23%. Subjects with orthostatic hypotension had significantly longer diabetes duration than subjects who were normotensive and those with orthostatic hypertension. Quantitatively, BP changes from supine to standing correlated with diabetes duration (R = 0.306; P = 0.0582) and age (R = 0.434; P = 0.006) in subjects with orthostatic hypotension.
Orthostatic hypertension and orthostatic hypotension are frequent in patients with DSP. Orthostatic hypertension is associated with shorter diabetes duration than orthostatic hypotension.
确定糖尿病感觉运动多发性神经病（DSP）患者中体位性低血压和体位性高血压的患病率及其相关临床特征。
对 200 名接受标准临床评估的 DSP 患者进行了一项单中心回顾性横断面研究，这些患者进行了 3 分钟的体位测量。我们测量了卧位和站立 3 分钟后的心率（HR）和血压（BP）。
体位性低血压的患病率为 19.5%，体位性高血压的患病率为 23%。与血压正常和体位性高血压的患者相比，体位性低血压患者的糖尿病病程明显更长。在体位性低血压患者中，从卧位到站立位的血压变化与糖尿病病程（R=0.306；P=0.0582）和年龄（R=0.434；P=0.006）呈正相关。
体位性高血压和体位性低血压在 DSP 患者中很常见。与体位性低血压相比，体位性高血压与较短的糖尿病病程相关。
