He Xing, Pan Weiqing
Department of Tropical Diseases, Navy Medical University, Shanghai, 200433, China.
Department of Tropical Diseases, Navy Medical University, Shanghai, 200433, China.
Trends Parasitol. 2022 Jun;38(6):478-488. doi: 10.1016/j.pt.2022.02.011. Epub 2022 Mar 18.
Parasitic diseases are still the common diseases that seriously threaten human health and life, and a better understanding of host-parasite interactions is the key to effectively controlling and ultimately eradicating these diseases. MicroRNAs (miRNAs) are ubiquitously expressed in almost all eukaryotic parasites and their hosts. These regulatory noncoding RNAs can be released by donor cells and absorbed by distant recipient cells within individual organisms. Recent studies illustrate numerous examples of cross-species miRNA exchanges within the context of host-parasite interactions. Here we review the literature demonstrating that cross-species miRNAs are consistently present in parasites or their hosts, and detail their functional responses in host defense or parasite survival and pathogenesis.
寄生虫病仍然是严重威胁人类健康和生命的常见疾病，更好地了解宿主与寄生虫的相互作用是有效控制并最终根除这些疾病的关键。微小RNA（miRNA）几乎在所有真核寄生虫及其宿主中普遍表达。这些具有调控作用的非编码RNA可由供体细胞释放，并被个体生物体内远处的受体细胞吸收。最近的研究表明，在宿主与寄生虫相互作用的背景下，存在大量跨物种miRNA交换的例子。在此，我们综述文献，证明跨物种miRNA始终存在于寄生虫或其宿主中，并详细阐述它们在宿主防御或寄生虫生存及发病机制中的功能反应。
