Judice Carla C, Bourgard Catarina, Kayano Ana C A V, Albrecht Letusa, Costa Fabio T M
Laboratory of Tropical Diseases, Department of Genetics, Evolution and Bioagents, University of Campinas UNICAMP, Campinas, Brazil.
Instituto Carlos Chagas, Fiocruz-Paraná Curitiba, Brazil.
Front Cell Infect Microbiol. 2016 Feb 2;6:5. doi: 10.3389/fcimb.2016.00005. eCollection 2016.
MicroRNAs (miRNAs), a class of small non-coding regulatory RNAs, have been detected in a variety of organisms ranging from ancient unicellular eukaryotes to mammals. They have been associated with numerous molecular mechanisms involving developmental, physiological and pathological changes of cells and tissues. Despite the fact that miRNA-silencing mechanisms appear to be absent in some Apicomplexan species, an increasing number of studies have reported a role for miRNAs in host-parasite interactions. Host miRNA expression can change following parasite infection and the consequences can lead, for instance, to parasite clearance. In this context, the immune system signaling appears to have a crucial role.
微小RNA（miRNA）是一类小的非编码调节RNA，已在从古老的单细胞真核生物到哺乳动物等多种生物体中被检测到。它们与许多涉及细胞和组织发育、生理及病理变化的分子机制相关。尽管在某些顶复门物种中似乎不存在miRNA沉默机制，但越来越多的研究报道了miRNA在宿主-寄生虫相互作用中的作用。寄生虫感染后宿主miRNA表达会发生变化，其结果可能导致，例如寄生虫被清除。在这种情况下，免疫系统信号传导似乎起着关键作用。
