Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88, Songpa-gu, Seoul, Korea.
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88, Songpa-gu, Seoul, Korea.
Clin Lymphoma Myeloma Leuk. 2022 Jul;22(7):e541-e548. doi: 10.1016/j.clml.2022.02.004. Epub 2022 Feb 24.
The clinical and pathological features of lymphomatoid papulosis (LYP) are diverse. The objective of this study is to evaluate the clinical and pathological features associated with the prognosis and clinical course of LYP.
The clinical and pathological features of LYP in a medical center database were retrospectively retrieved.
Overall, 58 LYP patients were included in the study. The mean age at diagnosis was 39.1 years and the female-to-male ratio was 1:1.2. More than two-thirds (40/58, 69.0%) of the patients showed a chronic and recurrent disease course. A longer pre-diagnosis duration (odds ratio (OR), 1.01; 95% confidence interval (CI), 1.00-1.03) was significantly associated with secondary lymphoma development. Lower extremity involvement (OR, 10.40; 95% CI, 1.17-92.28) and the absence of eosinophils in the lesions (OR, 11.28; 95% CI, 1.01-126.24) were found to be significantly associated with the chronic and recurrent course of LYP.
A longer pre-diagnosis duration is associated with secondary lymphoma, while a lower extremity involvement and the absence of lesional eosinophil infiltration are associated with the chronicity of LYP.
蕈样肉芽肿（LYP）的临床表现和病理特征多种多样。本研究旨在评估与 LYP 预后和临床病程相关的临床和病理特征。
本研究通过回顾性检索医疗中心数据库中 LYP 的临床和病理特征。
总体而言，本研究纳入了 58 例 LYP 患者。诊断时的平均年龄为 39.1 岁，男女比例为 1:1.2。超过三分之二（40/58，69.0%）的患者表现为慢性和复发性疾病过程。较长的预诊断时间（比值比（OR），1.01；95%置信区间（CI），1.00-1.03）与继发性淋巴瘤的发生显著相关。下肢受累（OR，10.40；95%CI，1.17-92.28）和病变中无嗜酸性粒细胞浸润（OR，11.28；95%CI，1.01-126.24）与 LYP 的慢性和复发性病程显著相关。
较长的预诊断时间与继发性淋巴瘤相关，而下肢受累和病变中无嗜酸性粒细胞浸润与 LYP 的慢性病程相关。
