Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran; Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Biochemistry, School of Medicine, Gorgan University of Medical Sciences, Urmia, Iran.
Clin Biochem. 2022 Jun;104:1-12. doi: 10.1016/j.clinbiochem.2022.03.002. Epub 2022 Mar 17.
Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.
新型冠状病毒病（COVID-19）由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起，迅速演变成全球卫生紧急事件。Neopterin[NPT]是巨噬细胞在受到干扰素[IFN-]γ刺激时产生的，是抗病毒免疫反应中的重要细胞因子。NPT 已被用作评估不同疾病严重程度的早期标志物。NPT 产生的主要原因是促炎细胞因子 IFN-。巨噬细胞的激活也被揭示与 SARS-CoV-2 患者的疾病严重程度有关。我们证明了 NPT 在 SARS-CoV-2 发病机制中的重要性，并提出针对 SARS-CoV-2 感染中的 NPT 可能是早期预测疾病进展和及时管理感染个体的关键。
