Tripathi Alok Shiomurti, Awasthi Saumya, Maurya Rahul Kumar, Yasir Mohammad, Mohapatra Lucy, Srivastav Vivek
Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
Microb Pathog. 2022 Apr;165:105493. doi: 10.1016/j.micpath.2022.105493. Epub 2022 Mar 18.
Present investigation evaluates the protective effect of vanillin against sepsis. Sepsis was induced by cecal ligation and puncture (CLP) in rat and vanillin was administered at dose of 100 and 200 mg/kg p.o. for five days after induction of sepsis. Effect of vanillin was observed on the percentage of survival, body weight and food intake were determined in CLP induced sepsis rats. Level of liver enzymes in the serum and organ weight was also observed in vanillin treated CLP induced rats. Moreover, histopathological changes were also observed in liver and lung tissue of hematoxylin and eosin (H&E) staining. There was significant improvement in bodyweight and food intake in vanillin treated group than negative control group after the sepsis induction. Moreover, vanillin improves the percentage of survival rate and reduces the level of liver enzymes and spleen weight in CLP induced sepsis rat. It also improves the level of glutathione (GSH) compared to negative control group. In conclusion, data of investigation reveals that vanillin ameliorates the survival rate and oxidative stress in CLP induced sepsis rat model.
目前的研究评估了香草醛对脓毒症的保护作用。通过盲肠结扎和穿刺（CLP）诱导大鼠发生脓毒症，并在脓毒症诱导后连续五天口服给予100和200 mg/kg剂量的香草醛。观察香草醛对CLP诱导的脓毒症大鼠存活率的影响，测定其体重和食物摄入量。还观察了香草醛处理的CLP诱导大鼠的血清肝酶水平和器官重量。此外，对苏木精和伊红（H&E）染色的肝和肺组织进行了组织病理学变化观察。脓毒症诱导后，香草醛处理组的体重和食物摄入量与阴性对照组相比有显著改善。此外，香草醛提高了CLP诱导的脓毒症大鼠的存活率，降低了肝酶水平和脾脏重量。与阴性对照组相比，它还提高了谷胱甘肽（GSH）水平。总之，研究数据表明香草醛可改善CLP诱导的脓毒症大鼠模型的存活率和氧化应激。
