小动物骨移植的放射自显影研究。

An autoradiographic study of bone grafts in small animals.

作者信息

Hildmann H, Tiedjen K U, Hildmann A

出版信息

Eur J Nucl Med. 1986;12(3):147-50. doi: 10.1007/BF00276708.

Abstract

Bone remodelling was studied in allografts and isografts by means of autoradiography. Collagen and proteoglycans of the organic bone matrix were labelled with H-3 amino acids and S-35 sodium sulphate. The principles of primary bone formation are followed in graft remodelling as well. Matrix breakdown and reformation are carried out by mononuclear cells. Components of the original matrix can be seen in osteoclasts, perivascular cells, osteoblasts, young osteocytes, and in new bone. The label allows tracing of these components and proves their reuse.

摘要

通过放射自显影术对同种异体移植骨和同基因移植骨中的骨重塑进行了研究。用H-3氨基酸和S-35硫酸钠对有机骨基质中的胶原蛋白和蛋白聚糖进行标记。移植骨重塑过程也遵循初级骨形成的原则。基质的分解和重塑由单核细胞完成。在破骨细胞、血管周围细胞、成骨细胞、年轻骨细胞以及新骨中都可以看到原始基质的成分。这种标记能够追踪这些成分并证明它们被重新利用。