Elves M W
Transplantation. 1975 May;19(5):416-23. doi: 10.1097/00007890-197505000-00009.
The degree of new bone formation in isografts and allografts has been assessed by a radiotracer technique. Allografts used have been either H-1-identical or H-1-disparate with the recipient. It was found that new bone formation is curtailed within the first 3 weeks after grafting. This curtailment was significantly greater in those donor-recipient combinations which were H-1-identical but disparate for many weak locus antigens than those in which H-1 disparity existed with only a few minor locus differences. There was no late phase (i.e., host-derived) osteogenesis in the combination with H-1 identity, but multiple minor antigen disparities. In isografts and H-1-disparate grafts significant late phase osteogenesis was found in about 30% of recipients. Resorption of the graft was found to be significantly impaired in both H-1-identical and disparate grafts in comparison with isografts. There was a significant negative correlation between weight of the graft and degree of osteogenesis in isografts during the first 2 weeks after grafting, and also during the later phase (6-8 weeks). A similar negative correlation was found during the late phase in H-1-disparate grafts with few minor antigen disparities, but no correlation was found at any time in H-1-identical grafts with multiple minor antigen disparities.
已通过放射性示踪技术评估了同基因移植物和异基因移植物中新骨形成的程度。所使用的异基因移植物与受体要么H-1相同，要么H-1不同。结果发现，移植后前3周内新骨形成受到抑制。在H-1相同但存在许多弱位点抗原差异的供体-受体组合中，这种抑制比仅存在少数次要位点差异的H-1不同的组合更为显著。在H-1相同但存在多个次要抗原差异的组合中，没有晚期（即宿主来源的）成骨现象。在同基因移植物和H-1不同的移植物中，约30%的受体出现了显著的晚期成骨现象。与同基因移植物相比，在H-1相同和不同的移植物中均发现移植物的吸收明显受损。在移植后的前2周以及后期（6-8周），同基因移植物中移植物的重量与成骨程度之间存在显著的负相关。在存在少数次要抗原差异的H-1不同的移植物的后期也发现了类似的负相关，但在存在多个次要抗原差异的H-1相同的移植物中，在任何时候都未发现相关性。
