Measurement Properties of Aerobic Capacity Measures in Neuromuscular Diseases: A Systematic Review.

OBJECTIVE

To systematically evaluate the measurement properties of aerobic capacity measures in neuromuscular diseases.

DATA SOURCES

MEDLINE, EMBASE, SportDiscus and Web of Science Conference Proceedings Citation Index - Science were systematically searched from inception until 30 June 2021.

STUDY SELECTION AND DATA EXTRACTION

Screening, data extraction, risk of bias assessment and quality assessment were performed by 2 independent researchers. Studies were included if they evaluated measurement properties of aerobic capacity measures in adults with neuromuscular diseases. Risk of bias was assessed using the COnsensus based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. Results were pooled and the quality of the evidence was determined using a modified Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

DATA SYNTHESIS

Nine studies including 187 participants were included in this review. Low quality of evidence was found for sufficient content validity of peak oxygen consumption through maximal exercise testing. Criterion validity of 4 out of 7 different measures to predict peak oxygen consumption was sufficient; however, quality of evidence was low or very low for all measures. No studies were found evaluating reliability or responsiveness.

CONCLUSION

There was a lack of high-quality studies with sufficiently large sample sizes that evaluated the measurement properties of aerobic capacity measures in neuromuscular diseases.