Department of Small Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee, USA.
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee, USA.
J Vet Pharmacol Ther. 2022 May;45(3):229-234. doi: 10.1111/jvp.13047. Epub 2022 Mar 20.
Cats and kittens in animal shelters and catteries regularly suffer from severe gastrointestinal coccidiosis, which can be fatal, and there are no drugs labeled for feline coccidiosis in the United States. Ponazuril, a triazine-class drug, is increasingly used at a dose of 50 mg/kg/d, orally, for three to five days in shelter environments for coccidiosis. A single oral dose of ponazuril paste 15% (Marquis ; Merial) at 50 mg/kg was administered to six healthy adult cats. Sample analysis was completed via high-performance liquid chromatography. Plasma concentrations peaked at 7.49 ± 2.06 µg/ml at 14.67 ± 7.45 hr post-administration. This study shows that ponazuril achieved a plasma concentration that inhibits growth of similar organisms after a single oral dose in cats. Further studies are necessary to optimize dosing for the treatment of clinical coccidiosis in cats.
动物收容所和饲养场中的猫和小猫经常患有严重的胃肠道球虫病，这可能是致命的，而且美国没有专门用于治疗猫球虫病的药物。噁二嗪类药物苯扎硝唑（ponazuril）在收容所环境中，以 50mg/kg/d 的剂量，口服，连续 3-5 天，越来越多地用于治疗球虫病。对六只健康成年猫口服给予 15%（马奎斯；梅里亚）苯扎硝唑糊剂 50mg/kg 的单剂量。通过高效液相色谱法完成样品分析。给药后 14.67±7.45 小时，血浆浓度峰值为 7.49±2.06µg/ml。这项研究表明，苯扎硝唑在猫中单次口服后，达到了抑制类似生物生长的血浆浓度。需要进一步研究以优化猫临床球虫病的治疗剂量。
