Schroers Jade E, Gilbert Alexander M, McKenzie Paul R, Kirwan Paul D, Chadban Steven J, Ying Tracey
Kidney Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Department of Tissue Pathology and Diagnostic Oncology, NSWHP, Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia.
Intern Med J. 2022 Mar;52(3):479-484. doi: 10.1111/imj.15702.
Crescents are not a well recognised feature of diabetic nephropathy. We present two cases of patients presenting with a rapid decline in renal function and subacute onset of nephrotic syndrome. Glomerulonephritis screening was negative, and renal biopsy revealed non-necrotising cellular crescents and typical features of late-stage diabetic nephropathy. We review the literature for diabetic nephropathy with crescents and explore possible underlying mechanisms.
新月体并非糖尿病肾病的一个广为人知的特征。我们报告两例患者，他们出现肾功能迅速下降及肾病综合征亚急性起病。肾小球肾炎筛查为阴性，肾活检显示非坏死性细胞性新月体及晚期糖尿病肾病的典型特征。我们回顾了有关伴有新月体的糖尿病肾病的文献，并探讨了可能的潜在机制。
