Kukačka Jan, Metz Stephan, Dehner Christoph, Muckenhuber Alexander, Paul-Yuan Korbinian, Karlas Angelos, Fallenberg Eva Maria, Rummeny Ernst, Jüstel Dominik, Ntziachristos Vasilis
Helmholtz Zentrum München (GmbH), Institute of Biological and Medical Imaging, Neuherberg, Germany.
Technical University of Munich, School of Medicine, Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), Munich, Germany.
Photoacoustics. 2022 Mar 2;26:100343. doi: 10.1016/j.pacs.2022.100343. eCollection 2022 Jun.
Since the initial breast transillumination almost a century ago, breast cancer imaging using light has been considered in different implementations aiming to improve diagnostics, minimize the number of available biopsies, or monitor treatment. However, due to strong photon scattering, conventional optical imaging yields low resolution images, challenging quantification and interpretation. Optoacoustic imaging addresses the scattering limitation and yields high-resolution visualization of optical contrast, offering great potential value for breast cancer imaging. Nevertheless, the image quality of experimental systems remains limited due to a number of factors, including signal attenuation with depth and partial view angle and motion effects, particularly in multi-wavelength measurements.
We developed data analytics methods to improve the accuracy of handheld optoacoustic breast cancer imaging, yielding second-generation optoacoustic imaging performance operating in tandem with ultrasonography.
We produced the most advanced images yet with handheld optoacoustic examinations of the human breast and breast cancer, in terms of resolution and contrast. Using these advances, we examined optoacoustic markers of malignancy, including vasculature abnormalities, hypoxia, and inflammation, on images obtained from breast cancer patients.
We achieved a new level of quality for optoacoustic images from a handheld examination of the human breast, advancing the diagnostic and theranostic potential of the hybrid optoacoustic-ultrasound (OPUS) examination over routine ultrasonography.
自近一个世纪前首次进行乳房透照以来，利用光进行乳腺癌成像已在不同的应用中得到考虑，旨在改善诊断、减少活检次数或监测治疗。然而，由于强烈的光子散射，传统光学成像产生的图像分辨率较低，给定量分析和解读带来挑战。光声成像解决了散射限制问题，能够对光学对比度进行高分辨率可视化，为乳腺癌成像提供了巨大的潜在价值。尽管如此，由于多种因素，包括信号随深度的衰减、部分视角和运动效应，特别是在多波长测量中，实验系统的图像质量仍然有限。
我们开发了数据分析方法，以提高手持式光声乳腺癌成像的准确性，从而实现与超声检查协同操作的第二代光声成像性能。
就分辨率和对比度而言，我们通过对手部进行光声检查，获得了迄今为止最先进的人体乳房和乳腺癌图像。利用这些进展，我们在从乳腺癌患者获得的图像上检查了恶性肿瘤的光声标志物，包括血管异常、缺氧和炎症。
我们通过对手部进行人体乳房检查，实现了光声图像质量的新水平，相对于常规超声检查，提升了光声 - 超声（OPUS）联合检查的诊断和治疗诊断潜力。
