Pylväs-Korolainen Minna, Karjalainen Karoliina, Lintonen Tomi
University of Helsinki, Finland.
Finnish Institute for Health and Welfare, Helsinki, Finland.
Nordisk Alkohol Nark. 2022 Feb;39(1):50-63. doi: 10.1177/14550725211003417. Epub 2021 Apr 22.
Psychoactive prescription drugs are known to have abuse potential. This study was aimed at studying the non-medical use of prescription drugs (NMUPD) among individuals with prescriptions for anxiolytics, sedatives, or strong analgesics. We examined the association of socio-demographics, binge drinking, the number of drug prescriptions, and drug types prescribed for medical purposes with NMUPD among the general Finnish population.
Data were derived from population-based (ages 15-69 years) Drug Surveys conducted in Finland in 2006, 2010, and 2014. The response rates varied between 48% and 55%. Individuals with prescriptions for one or more prescription drugs in the last 12 months were included ( = 1,602) and divided into three groups: medical use only, NMUPD, and NMUPD with illicit drug use (ILLICIT USE). Multinomial logistic regression was used.
Among individuals with a prescription for at least one prescription drug, 5.7% reported NMUPD. Living alone and being outside the labour force were associated with NMUPD. Younger age, living in a large city, living alone, and unemployment were associated with ILLICIT USE. Frequent binge drinking and a high number of drug prescriptions were associated with both NMUPD and ILLICIT USE. Those reporting ILLICIT USE were more likely to have a prescription for sedatives.
Although NMUPD is on a rather low level among those who have a prescription for legitimate purposes, having multiple prescriptions increased the likelihood of NMUPD. Low socio-economic position and binge drinking are associated with NMUPD and this should be taken into account when planning interventions and preventive actions.
已知精神活性处方药具有滥用可能性。本研究旨在调查开具抗焦虑药、镇静剂或强效镇痛药处方的人群中处方药的非医疗用途(NMUPD)。我们研究了芬兰普通人群中社会人口统计学特征、暴饮、药物处方数量以及用于医疗目的的药物类型与NMUPD之间的关联。
数据来源于2006年、2010年和2014年在芬兰开展的基于人群(年龄15 - 69岁)的药物调查。应答率在48%至55%之间。纳入过去12个月内开具一种或多种处方药的个体(n = 1602),并将其分为三组:仅医疗用途、NMUPD以及伴有非法药物使用的NMUPD(非法使用)。采用多项逻辑回归分析。
在至少开具一种处方药的个体中,5.7%报告有NMUPD。独居和未就业与NMUPD相关。较年轻、居住在大城市、独居和失业与非法使用相关。频繁暴饮和大量药物处方与NMUPD及非法使用均相关。报告有非法使用的个体更有可能开具镇静剂处方。
尽管在有合法处方的人群中NMUPD水平相对较低,但开具多种处方会增加NMUPD的可能性。社会经济地位低和暴饮与NMUPD相关,在规划干预措施和预防行动时应予以考虑。