Zhang Menggang, Xiong Fei, Zhang Shuijun, Guo Wenzhi, He Yuting
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Med (Lausanne). 2022 Mar 4;9:845094. doi: 10.3389/fmed.2022.845094. eCollection 2022.
Genetic and epigenetic characteristics are core factors of cancer. MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression at the post-transcriptional level binding to corresponding mRNAs. Recently, increasing evidence has proven that miRNAs regulate the occurrence and development of human cancer. Here, we mainly review the abnormal expression of miR-625 in a variety of cancers. In summarizing the role and potential molecular mechanisms of miR-625 in various tumors in detail, we reveal that miR-625 is involved in a variety of biological processes, such as cell proliferation, invasion, migration, apoptosis, cell cycle regulation, and drug resistance. In addition, we discuss the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks and briefly explain the specific mechanisms of competing endogenous RNAs. In conclusion, we reveal the potential value of miR-625 in cancer diagnosis, treatment, and prognosis and hope to provide new ideas for the clinical application of miR-625.
遗传和表观遗传特征是癌症的核心因素。微小RNA（miRNA）是一类小的非编码RNA，可在转录后水平通过与相应的信使核糖核酸（mRNA）结合来调控基因表达。最近，越来越多的证据表明，miRNA调控人类癌症的发生和发展。在此，我们主要综述miR-625在多种癌症中的异常表达。在详细总结miR-625在各种肿瘤中的作用及潜在分子机制时，我们发现miR-625参与多种生物学过程，如细胞增殖、侵袭、迁移、凋亡、细胞周期调控及耐药性。此外，我们讨论了长链非编码RNA（lncRNA）-miRNA-mRNA和环状RNA（circRNA）-miRNA-mRNA网络，并简要解释了竞争性内源RNA的具体机制。总之，我们揭示了miR-625在癌症诊断、治疗及预后方面的潜在价值，希望为miR-625的临床应用提供新思路。
