Laboratório de Imunidade Natural, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil.
Front Immunol. 2022 Mar 3;13:849340. doi: 10.3389/fimmu.2022.849340. eCollection 2022.
Interleukin-32 (IL-32) has several immune regulatory properties, which have driven its investigation in the context of various diseases. IL-32 expression is reported to be induced in the lesions of patients with American tegumentary leishmaniasis (ATL) by the New World spp. that are responsible for causing ATL and visceral leishmaniasis (VL). IL-32 expression may elevate the inflammatory process through the induction of pro-inflammatory cytokines and also mechanisms directed to kill the parasites. The genetic variants of IL-32 might be associated with the resistance or susceptibility to ATL, while different isoforms of IL-32 could be associated with distinct T helper lymphocyte profiles. IL-32 also determines the transcriptional profile in the bone marrow progenitor cells to mediate the trained immunity induced by β-glucan and BCG, thereby contributing to the resistance against . IL-32γ is essential for the vitamin D-dependent microbicidal pathway for parasite control. In this context, the present review report briefly discusses the data retrieved from the studies conducted on IL-32 in leishmaniasis in humans and mice to highlight the current challenges to understanding the role of IL-32 in leishmaniasis.
白细胞介素-32 (IL-32) 具有多种免疫调节特性，这促使人们在各种疾病的背景下对其进行研究。据报道，新世界 spp. 引起的美洲皮肤利什曼病 (ATL) 和内脏利什曼病 (VL) 患者的病变中诱导表达 IL-32。IL-32 表达可能通过诱导促炎细胞因子和针对寄生虫的杀伤机制来加重炎症过程。IL-32 的遗传变异可能与 ATL 的抗性或易感性有关，而不同的 IL-32 同工型可能与不同的辅助性 T 淋巴细胞表型有关。IL-32 还决定骨髓祖细胞中的转录谱，以介导 β-葡聚糖和卡介苗诱导的训练性免疫，从而有助于抵抗 。IL-32γ 对于依赖维生素 D 的寄生虫控制杀菌途径是必不可少的。在这方面，本综述简要讨论了从人类和小鼠利什曼病中进行的关于 IL-32 的研究中获得的数据，以突出目前对理解 IL-32 在利什曼病中的作用的挑战。
