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利用混合频率磁辐射控制心肌细胞电活动中的放电模式。

Controlling discharge mode in electrical activities of myocardial cell using mixed frequencies magnetic radiation.

作者信息

Ntahkie Takembo Clovis, Kofane Timoleon Crepin

机构信息

Department of Electrical and Electronic Engineering, College of Technology, University of Buea I, P.O. Box 63, Buea, Cameroon.

Laboratory of Biophysics, Department of Physics, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.

出版信息

Heliyon. 2022 Mar 10;8(3):e09084. doi: 10.1016/j.heliyon.2022.e09084. eCollection 2022 Mar.

Abstract

Based on the standard Fitzhugh-Nagumo model for myocardial cell excitations and electrical activities, the effect of electromagnetic induction is considered and through which mixed frequencies magnetic radiation is imposed to detect the mode transition. Indeed, time-varying electromagnetic field can be induced when myocardial cell is exposed or surrounded by electromagnetic field and thus the effect of electromagnetic induction should be considered. From the analyzes of sampled series for membrane potentials, the improved model holds many bifurcation parameters and the mode of excitations and electric activities can be detected and observed in larger parameter zones. It is found that apart from exciting a myocardial cell, the mixed frequencies magnetic radiation can promote mode transition to bursting type behavior as the frequency is increased as well as suppress the electrical activities to quiescent state under high intensities magnetic radiations, which are consistent with biological experiments.

摘要

基于用于心肌细胞兴奋和电活动的标准菲茨休-纳古莫模型,考虑了电磁感应效应,并通过施加混合频率磁辐射来检测模式转变。实际上,当心肌细胞暴露于电磁场或被电磁场包围时,会感应出时变电磁场,因此应考虑电磁感应效应。通过对膜电位采样序列的分析,改进后的模型具有许多分岔参数,并且可以在更大的参数区域中检测和观察到兴奋和电活动模式。研究发现,除了激发心肌细胞外,混合频率磁辐射随着频率增加可促进模式转变为爆发型行为,并且在高强度磁辐射下可将电活动抑制到静止状态,这与生物学实验结果一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a775/8924321/95d9a072ad02/gr001.jpg

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