Takembo Clovis Ntahkie, Ekonde Sone Michael
Department of Electrical and Electronic Engineering, College of Technology, University of Buéa, P.O. Box 63, Buéa, Cameroon.
Heliyon. 2021 Jan 28;7(1):e06132. doi: 10.1016/j.heliyon.2021.e06132. eCollection 2021 Jan.
Biological neurons exposed to an external electric field can induce polarization and charge fluctuation. Indeed, the exchange of calcium, sodium and potassium ions across the cell membrane can induce an electric field as a result of a time-varying electromagnetic field set up. This field could further modulate the cell electrical activity by inducing multiple firing modes. Based on the physical law of electric field, an improved model which includes an additive electrical field variable is constructed for a network of neurons to study wave propagation and mode transition by exploring the longtime dynamics of slightly perturbed plane waves in the network. Wave pattern and mode transition dependence on the different parameters of external electric field are discussed. It is found that the plane wave propagating in the coupled system breaks down to localized structures under the activation of modulational instability. The network under high-low external electric field supports bursting synchronization. This could be a fruitful avenue to discern the occurrence of paroxysmal epilepsy.
暴露于外部电场的生物神经元可诱导极化和电荷波动。实际上，钙、钠和钾离子跨细胞膜的交换会由于时变电磁场的建立而感应出电场。该电场可通过诱导多种放电模式进一步调节细胞电活动。基于电场的物理定律，构建了一个包含附加电场变量的改进模型，用于研究神经元网络中的波传播和模式转变，通过探索网络中微扰平面波的长期动力学来实现。讨论了波形和模式转变对外部电场不同参数的依赖性。研究发现，在调制不稳定性的激活下，耦合系统中传播的平面波会分解为局域结构。高低外部电场下的网络支持爆发同步。这可能是识别阵发性癫痫发生的一条富有成效的途径。
