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一项利用骨密度和FRAX评分预测维持性血液透析患者骨折风险的研究。

A study to predict fracture risk using bone mineral density and FRAX score in patients on chronic maintenance haemodialysis.

作者信息

Patro Sunil K, Pawar Neeraj, Biswas Diwashish

机构信息

Department of General Medicine, AIIMS, Bhopal, Madhya Pradesh, India.

Department of Community and Family Medicine, AIIMS, Bhopal, Madhya Pradesh, India.

出版信息

J Family Med Prim Care. 2022 Jan;11(1):170-175. doi: 10.4103/jfmpc.jfmpc_901_21. Epub 2022 Jan 31.

DOI:10.4103/jfmpc.jfmpc_901_21
PMID:35309612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8930127/
Abstract

INTRODUCTION

Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are important causes of morbidity also their diagnosis often delayed and require a spectrum of investigations. The current study attempts to predict and correlate, the fracture risk using simple tools like BMD and FRAX (Fracture Risk Assessment Tool) score in CKD patients.

METHODS

A cross-sectional study among 50 CKD patients age more that 40 years attending OPD (Out Patient Department) at a tertiary care Hospital in north India.

RESULTS

There is a negative correlation between BMD (NOF) and FRAX score for hip fracture risk and major osteoporotic fracture risk.

CONCLUSION

The 10-year fracture risk in these patients, as predicted by FRAX score using FRAX (Indian) calculator, was significantly higher in CKD patients.

RECOMMENDATION

FRAX can be useful tool for early screening of fracture risk in such situations for timely interventions.

摘要

引言

矿物质和骨代谢紊乱在慢性肾脏病（CKD）中普遍存在，是发病的重要原因，其诊断往往延迟，需要一系列检查。本研究试图使用如骨密度（BMD）和FRAX（骨折风险评估工具）评分等简单工具，对CKD患者的骨折风险进行预测并建立相关性。

方法

在印度北部一家三级医院门诊部对50名年龄超过40岁的CKD患者进行横断面研究。

结果

BMD（NOF）与髋部骨折风险和主要骨质疏松性骨折风险的FRAX评分之间存在负相关。

结论

使用FRAX（印度）计算器通过FRAX评分预测，这些患者的10年骨折风险在CKD患者中显著更高。

建议

在这种情况下，FRAX可作为早期筛查骨折风险以进行及时干预的有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/b6cbfb027ad4/JFMPC-11-170-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/2a31271ae0e7/JFMPC-11-170-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/c67e858a3a4f/JFMPC-11-170-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/7a7023c9bb7b/JFMPC-11-170-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/b6cbfb027ad4/JFMPC-11-170-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/2a31271ae0e7/JFMPC-11-170-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/c67e858a3a4f/JFMPC-11-170-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/7a7023c9bb7b/JFMPC-11-170-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27b/8930127/b6cbfb027ad4/JFMPC-11-170-g004.jpg

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The risk of new fragility fractures in patients with chronic kidney disease and hip fracture-a population-based cohort study in the UK.患有慢性肾脏病和髋部骨折的患者发生新脆性骨折的风险：英国一项基于人群的队列研究。
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印度慢性肾脏病患者骨健康的无创评估
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