Sonié Pedro, Manuel-Silva Jorge, Rafael Alexandra, Amorim-Alves Luís
Department of Family Medicine, Health Family Unit of Arco do Prado, Vila Nova de Gaia, Portugal.
Department of Family Medicine, Health Family Unit of St. André de Canidelo, Vila Nova de Gaia, Portugal.
J Family Med Prim Care. 2022 Jan;11(1):366-369. doi: 10.4103/jfmpc.jfmpc_1490_21. Epub 2022 Jan 31.
Data show that antibody-related immunity against SARS-CoV-2 may not be long-lasting. We report two cases regarded as cured from COVID-19, which presented again with symptoms and a positive SARS-CoV-2 RT-PCR test. Case one, a 60-year-old male, had a biphasic presentation of symptoms compatible with COVID-19 infection, associated with a positive RT-PCR test. Case two, a 25-year-old female, had a first positive RT-PCR test during hospital screening, and months later a symptomatic presentation of COVID-19, associated with a positive RT-PCR test. All cases were immunocompetent. Anti-IgG-SARS-CoV-2 blood samples were negative in both. Elevation of analytical inflammatory markers suggested new infection in both cases. COVID-19 reinfection may be a differential diagnosis and primary care physicians should acknowledge it. Previously cured patients should be encouraged to comply with health public preventive measures.
数据显示，针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的抗体相关免疫可能不会持久。我们报告了两例被视为新冠病毒病（COVID-19）治愈的病例，这两例病例再次出现症状且严重急性呼吸综合征冠状病毒2逆转录聚合酶链反应（SARS-CoV-2 RT-PCR）检测呈阳性。病例一为一名60岁男性，有与COVID-19感染相符的双相症状表现，同时逆转录聚合酶链反应检测呈阳性。病例二为一名25岁女性，在医院筛查期间首次逆转录聚合酶链反应检测呈阳性，数月后出现COVID-19症状表现，同时逆转录聚合酶链反应检测呈阳性。所有病例免疫功能正常。两例患者的抗严重急性呼吸综合征冠状病毒2免疫球蛋白G（Anti-IgG-SARS-CoV-2）血样均为阴性。分析性炎症标志物升高提示两例均为新感染。COVID-19再次感染可能是一种鉴别诊断，基层医疗医生应认识到这一点。应鼓励先前治愈的患者遵守公共卫生预防措施。
