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在无抗原情况下于体外暴露于重组白细胞介素-2的自体淋巴细胞可诱导对长期耐受的皮肤同种异体移植物的排斥反应。

Autologous lymphoid cells exposed to recombinant interleukin-2 in vitro in the absence of antigen can induce the rejection of long-term tolerated skin allografts.

作者信息

Loveland B, Hunt R, Malkovský M

出版信息

Immunology. 1986 Sep;59(1):159-61.

PMID:3530983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453132/
Abstract

The intraperitoneal (i.p.) administration of autologous spleen cells treated with recombinant interleukin-2 (IL-2) in vitro resulted in the rejection of C57BL/10ScSn (B10) skin grafts that had survived for 18 months on CBA/Ca mice tolerant to B10 alloantigens. Cytotoxic lymphocytes specific for the graft alloantigens, assayed by limiting dilution analysis, appeared after the breaking of this immunological tolerance, whereas they were not detectable in tolerant mice. In these mice the frequencies of precursor cytotoxic cells specific for third-party alloantigens were unaffected by the IL-2 treatment.

摘要

在体外经重组白细胞介素-2（IL-2）处理的自体脾细胞腹腔内（i.p.）给药，导致在对B10同种异体抗原耐受的CBA/Ca小鼠身上存活了18个月的C57BL/10ScSn（B10）皮肤移植物被排斥。通过有限稀释分析检测，针对移植物同种异体抗原的细胞毒性淋巴细胞在这种免疫耐受被打破后出现，而在耐受小鼠中则检测不到。在这些小鼠中，针对第三方同种异体抗原的前体细胞毒性细胞频率不受IL-2处理的影响。

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Autologous lymphoid cells exposed to recombinant interleukin-2 in vitro in the absence of antigen can induce the rejection of long-term tolerated skin allografts.在无抗原情况下于体外暴露于重组白细胞介素-2的自体淋巴细胞可诱导对长期耐受的皮肤同种异体移植物的排斥反应。
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本文引用的文献

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Immunological tolerance.
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Transplantation tolerance: Lyt-1+2- helper T cells require a second proliferation signal to overcome Lyt- 1-2+ suppressor T cell activity.移植耐受：Lyt-1+2-辅助性T细胞需要第二个增殖信号来克服Lyt-1-2+抑制性T细胞的活性。
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T cell signals: tolerance to DNFB is converted to sensitization by a separate nonspecific second signal.T细胞信号：对二硝基氟苯的耐受性通过一个独立的非特异性第二信号转变为致敏状态。
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A diet enriched in vitamin A acetate or in vivo administration of interleukin-2 can counteract a tolerogenic stimulus.
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10
An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
Transplantation. 1968 Sep;6(6):761-4. doi: 10.1097/00007890-196809000-00002.

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