N Chin Christopher, Subhawong Ty, Grosso James, Wortman Jeremy R, McIntosh Lacey J, Tai Ryan, Braschi-Amirfarzan Marta, Castillo Patricia, Alessandrino Francesco
Department of Surgery, Leonard M. Miller School of Medicine, Miami, FL, USA.
Department of Radiology, Leonard M. Miller School of Medicine, Miami, FL, USA.
Eur J Radiol Open. 2022 Mar 15;9:100414. doi: 10.1016/j.ejro.2022.100414. eCollection 2022.
The role of imaging in cancer diagnosis and treatment has evolved at the same rapid pace as cancer management. Over the last twenty years, with the advancement of technology, oncology has become a multidisciplinary field that allows for researchers and clinicians not only to create individualized treatment options for cancer patients, but also to evaluate patients' response to therapy with increasing precision. Familiarity with these concepts is a requisite for current and future radiologists, as cancer imaging studies represent a significant and growing component of any radiology practice, from tertiary cancer centers to community hospitals. In this review we provide the framework to teach cancer imaging in the era of genomic oncology. After reading this article, readers should be able to illustrate the basics cancer genomics, modern cancer genomics, to summarize the types of systemic oncologic therapies available, their patterns of response and their adverse events, to discuss the role of imaging in oncologic clinical trials and the role of tumor response criteria and to display the future directions of oncologic imaging.
成像在癌症诊断和治疗中的作用与癌症管理一样迅速发展。在过去二十年中，随着技术的进步，肿瘤学已成为一个多学科领域，使研究人员和临床医生不仅能够为癌症患者制定个性化的治疗方案，还能越来越精确地评估患者对治疗的反应。熟悉这些概念是当前和未来放射科医生的必备条件，因为癌症成像研究在从三级癌症中心到社区医院的任何放射学实践中都占了很大且不断增长的比重。在这篇综述中，我们提供了在基因组肿瘤学时代教授癌症成像的框架。阅读本文后，读者应能够阐述癌症基因组学的基础知识、现代癌症基因组学，总结可用的全身肿瘤治疗方法的类型、它们的反应模式及其不良事件，讨论成像在肿瘤临床试验中的作用以及肿瘤反应标准的作用，并展示肿瘤成像的未来方向。
