Li Jun, Zhang Na, Li Meihua, Hong Tao, Meng Wei, Ouyang Taohui
Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Jiangxi, China.
Department of the Second Clinical Medical College of Nanchang University, Jiangxi, China.
Front Cell Dev Biol. 2022 Mar 2;10:820781. doi: 10.3389/fcell.2022.820781. eCollection 2022.
Ovarian tumor (OTU) domain-containing ubiquitin aldehyde-binding protein Otubain2 (OTUB2) was a functional cysteine protease in the OTU family with deubiquitinase activity. In recent years, with the wide application of molecular biology techniques, molecular mechanism regulation at multiple levels of cell signaling pathways has been gradually known, such as ubiquitin-mediated protein degradation and phosphorylation-mediated protein activation. OTUB2 is involved in the deubiquitination of many key proteins in different cell signaling pathways, and the effect of OTUB2 on human health or disease is not clear. OTUB2 is likely to cause cancer and other malignant diseases while maintaining normal human development and physiological function. Therefore, it is of great value to comprehensively understand the regulatory mechanism of OTUB2 and regard it as a target for the treatment of diseases. This review makes a general description and appropriate analysis of OTUB2's regulation in different cell signaling pathways, and connects OTUB2 with cancer from the research hotspot perspective of DNA damage repair and immunity, laying the theoretical foundation for future research.
含卵巢肿瘤（OTU）结构域的泛素醛结合蛋白奥特宾2（OTUB2）是OTU家族中具有去泛素酶活性的功能性半胱氨酸蛋白酶。近年来，随着分子生物学技术的广泛应用，细胞信号通路多个层面的分子机制调控已逐渐为人所知，如泛素介导的蛋白质降解和磷酸化介导的蛋白质激活。OTUB2参与不同细胞信号通路中许多关键蛋白的去泛素化，而OTUB2对人类健康或疾病的影响尚不清楚。OTUB2在维持人类正常发育和生理功能的同时，可能引发癌症等恶性疾病。因此，全面了解OTUB2的调控机制并将其作为疾病治疗靶点具有重要价值。本文综述对OTUB2在不同细胞信号通路中的调控进行了概述和适当分析，并从DNA损伤修复和免疫的研究热点角度将OTUB2与癌症联系起来，为未来研究奠定理论基础。
