Chen Chang, Chen Yequn, Xiao Jiaxin, Zhang Yanhong, Yang Zhaorui, Yang Peixuan, Lu Nan, Yi Kaihong, Chen Xiaojun, Chen Shaoxin, O'Gara MSc Mary Clare, O'Meara Michael, Ye Shu, Tan Xuerui
The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Shantou University Medical College, Shantou, China.
Front Cell Dev Biol. 2022 Mar 3;10:820124. doi: 10.3389/fcell.2022.820124. eCollection 2022.
The association between impaired fasting glucose level (IFG) and coronary heart disease (CAD) remain controversial. In the present study, we sought to ascertain a relationship of IFG with the number of diseased coronary artery and occurrence of myocardial infarction, among CAD cases. We studied 1,451 consecutive no-diabetic patients who underwent coronary angiography at the First Affiliated Hospital of Shantou University Medical College in Southern China. Demographic, biochemical, clinical and angiographic data were collected. The prevalence of IFG was higher in patients with angiographically confirmed CAD than in subjects without angiographic evidence of CAD (33.4 28.2%, = 0.034). Compared with CAD cases without IFG, CAD cases with IFG had a higher odds ratio (OR) of having triple-vessel disease as opposed to having single- or double-vessel disease [OR = 1.53, 95% confidence interval (CI) = 1.13-2.07]. Furthermore, the occurrence of MI was higher in CAD cases with IFG than in CAD cases without IFG (OR = 1.73, 95% CI = 1.27-2.36). There is an association between IFG and a predisposition to severe CAD indicated by triple vessel disease or myocardial infarction.
空腹血糖受损水平（IFG）与冠心病（CAD）之间的关联仍存在争议。在本研究中，我们试图确定在CAD病例中IFG与病变冠状动脉数量及心肌梗死发生之间的关系。我们研究了在中国南方汕头大学医学院第一附属医院连续接受冠状动脉造影的1451例非糖尿病患者。收集了人口统计学、生化、临床和血管造影数据。血管造影证实患有CAD的患者中IFG的患病率高于无血管造影证据的CAD患者（33.4%对28.2%，P = 0.034）。与无IFG的CAD病例相比，有IFG的CAD病例发生三支血管病变而非单支或双支血管病变的优势比（OR）更高[OR = 1.53，95%置信区间（CI）= 1.13 - 2.07]。此外，有IFG的CAD病例中心肌梗死的发生率高于无IFG的CAD病例（OR = 1.73，95%CI = 1.27 - 2.36）。IFG与由三支血管病变或心肌梗死所表明的严重CAD易感性之间存在关联。
