Su Shenghui, Tang Qiangqiang, Qu Dongbin
Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Front Bioeng Biotechnol. 2022 Mar 4;10:856986. doi: 10.3389/fbioe.2022.856986. eCollection 2022.
Zinc and its alloys are considered to be next-generation materials for fabricating absorbable biomedical devices. However, cytotoxicity has been reported to be associated with rapid degradation. To address these issues, a composite coating (PLA/Li-OCP) consisting of CaHPO conversion coating (Ca-P) and polylactic acid (PLA) decorated with Li-octacalcium phosphate particles was constructed on pure zinc. The immersion tests showed that the presence of Ca-P coating and PLA/Li-OCP coating on pure zinc could reduce the pH value. Compared with Ca-P coating, the introduction of the PLA/Li-OCP film on the Ca-P-coated samples could enhance the corrosion resistance, and there was one order of magnitude decrease in the corrosion current density. The cytocompatibility assay suggested that the PLA/Li-OCP coating favored the cell viability and upregulated the expression of related osteogenic-genes including RUNX2, OCN, and BMP. Therefore, the presence of the PLA/Li-OCP coating on pure zinc could effectively improve the degradation rate and cytocompatibility of pure zinc.
锌及其合金被认为是制造可吸收生物医学装置的下一代材料。然而，据报道细胞毒性与快速降解有关。为了解决这些问题，在纯锌上构建了一种复合涂层（PLA/Li-OCP），该涂层由磷酸氢钙转化涂层（Ca-P）和装饰有磷酸八钙锂颗粒的聚乳酸（PLA）组成。浸泡试验表明，纯锌上存在Ca-P涂层和PLA/Li-OCP涂层可降低pH值。与Ca-P涂层相比，在Ca-P涂层样品上引入PLA/Li-OCP膜可提高耐腐蚀性，腐蚀电流密度降低了一个数量级。细胞相容性分析表明，PLA/Li-OCP涂层有利于细胞活力，并上调了包括RUNX2、OCN和BMP在内的相关成骨基因的表达。因此，纯锌上存在PLA/Li-OCP涂层可有效提高纯锌的降解速率和细胞相容性。
