Research School of Engineering, Australian National University, ACT, 2601, Australia.
John Curtin School of Medical Research, Australian National University, ACT, 2601, Australia.
Biomaterials. 2019 Oct;219:119366. doi: 10.1016/j.biomaterials.2019.119366. Epub 2019 Jul 15.
Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implants by systematically biomimicking the physiological processes involved in formation and functioning of bones.
生物医学植入物已广泛应用于各种骨科治疗，包括全髋关节置换术、关节融合术、骨折固定、骨不连、牙科修复等。骨科植入物的现代研究和开发已逐渐从传统的机械支撑转向生物活性移植物，以赋予其更好的成骨诱导和骨传导能力。本综述受天然骨结构和力学性能的启发，提供了当前促进医用植入物与骨组织相互作用的生物表面改性的全景图，并对通过系统仿生骨骼形成和功能涉及的生理过程来制造下一代多功能和智能植入物进行了未来展望。
