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皮拉希病毒：巴西南部一种新的潜在新兴虫媒病毒的鉴定

Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil.

作者信息

Tschá Marcel Kruchelski, Suzukawa Andreia A, Rodrigues-Luiz Gabriela Flavia, da Silva Allan Martins, Cataneo Allan Henrique Depieri, Mattoso Coelho Gabriela, Ferreira Adão Celestino, Soares Medeiros Lia Carolina, Mansur Daniel, Zanluca Camila, Duarte Dos Santos Claudia N

机构信息

Laboratório de Virologia Molecular, Instituto Carlos Chagas/Fiocruz-PR, Rua Prof. Algacyr Munhoz Mader 3775, Curitiba, PR 81350-010, Brazil.

Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas (CCB), Universidade Federal de Santa Catarina (UFSC), Av. Prof. Henrique da Silva Fontes 2754, Florianópolis, SC 88040-900, Brazil.

出版信息

Virus Evol. 2021 Dec 17;7(2):veab105. doi: 10.1093/ve/veab105. eCollection 2021 Sep.

DOI:10.1093/ve/veab105
PMID:35310294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8928568/
Abstract

Genomic and epidemiological surveillance are paramount for the discovery of new viruses with the potential to cross species barriers. Here, we present a new member of the genus found in and mosquitoes, tentatively named Pirahy virus (PIRAV). PIRAV was isolated from mosquito pools collected in a rural area of Piraí do Sul, South Brazil. assays revealed that PIRAV replicates and causes cytopathic effects in vertebrate cell lines such as Vero E6, SH-SY5Y, BHK-21 and UMNSAH/DF-1. Genomic signature analysis supports these results showing a dinucleotide and codon usage balance compatible with several hosts. Phylogenetic analyses placed PIRAV basal to the Venezuelan equine encephalitis complex. Genome analyses, electron microscopy, and biological characterization show findings that may alert for the emergence of a new arbovirus in South America.

摘要

基因组和流行病学监测对于发现具有跨物种屏障潜力的新病毒至关重要。在此，我们展示了在伊蚊和按蚊中发现的该属新成员，暂命名为皮拉伊病毒（PIRAV）。PIRAV是从巴西南部南皮拉伊农村地区收集的蚊群中分离出来的。检测显示，PIRAV在Vero E6、SH-SY5Y、BHK-21和UMNSAH/DF-1等脊椎动物细胞系中复制并引起细胞病变效应。基因组特征分析支持这些结果，表明其二核苷酸和密码子使用平衡与多种宿主兼容。系统发育分析将PIRAV置于委内瑞拉马脑炎复合体的基部。基因组分析、电子显微镜检查和生物学特征显示的结果可能为南美洲出现一种新的虫媒病毒敲响警钟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/73faa5a08509/veab105f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/954c83cc80df/veab105f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/2454626020f9/veab105f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/2dc578b352d3/veab105f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/e30e2c2f1471/veab105f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/f16e4e9fe2ea/veab105f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/a0bf7efce120/veab105f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/73faa5a08509/veab105f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/954c83cc80df/veab105f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/2454626020f9/veab105f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/2dc578b352d3/veab105f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/e30e2c2f1471/veab105f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/f16e4e9fe2ea/veab105f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/a0bf7efce120/veab105f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3352/8928568/73faa5a08509/veab105f7.jpg

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