Price Elliott J, Vitale Chiara M, Miller Gary W, David Arthur, Barouki Robert, Audouze Karine, Walker Douglas I, Antignac Jean-Philippe, Coumoul Xavier, Bessonneau Vincent, Klánová Jana
RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno 60200, Czech Republic.
Faculty of Sports Studies, Masaryk University, Kamenice 753/5, Brno 62500, Czech Republic.
iScience. 2022 Feb 24;25(3):103976. doi: 10.1016/j.isci.2022.103976. eCollection 2022 Mar 18.
The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual's health over their life course. However, disconnect between the concept and practical application has promoted divergent interpretations of the exposome across disciplines and reinforced separation of the environmental (emphasizing exposures) and biological (emphasizing responses) research communities. In particular, while knowledge of biological responses can help to distinguish actual (i.e. experienced) from potential exposures, the inclusion of endogenous processes has generated confusion about the position of the exposome in a multi-omics systems biology context. We propose a reattribution of "exposome" to exclusively represent the totality of contact with external factors that a biological entity experiences, and introduce the term "functional exposomics" to denote the systematic study of exposure-phenotype interaction. This reoriented definition of the exposome allows a more readily integrable dataset for multi-omics and systems biology research.
暴露组概念鼓励全面考虑在个体生命历程中影响其健康的非遗传因素（包括生活方式在内的环境暴露）。然而，该概念与实际应用之间的脱节促使各学科对暴露组产生了不同的解释，并强化了环境（强调暴露）和生物学（强调反应）研究群体之间的分离。特别是，虽然对生物学反应的了解有助于区分实际（即经历过的）暴露与潜在暴露，但内源性过程的纳入引发了关于暴露组在多组学系统生物学背景下地位的困惑。我们建议将“暴露组”重新定义为专门代表生物实体所经历的与外部因素接触的总和，并引入“功能暴露组学”一词来表示对暴露-表型相互作用的系统研究。这种对暴露组的重新定义为多组学和系统生物学研究提供了一个更容易整合的数据集。
