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一种用于胃穿孔密封和治疗的粘性弹性水凝胶。

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation.

作者信息

Chen Jing, Caserto Julia S, Ang Ida, Shariati Kaavian, Webb James, Wang Bo, Wang Xi, Bouklas Nikolaos, Ma Minglin

机构信息

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.

出版信息

Bioact Mater. 2021 Dec 17;14:52-60. doi: 10.1016/j.bioactmat.2021.11.038. eCollection 2022 Aug.

DOI:10.1016/j.bioactmat.2021.11.038
PMID:35310345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8892218/
Abstract

Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, to be effective, the hydrogels must have sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability and ideally are easy to apply and form. Herein, we report an adhesive and resilient hydrogel for the sealing and treatment of gastric perforation. The hydrogel consists of a bioactive, transglutaminase (TG)-crosslinked gelatin network and a dynamic, borate-crosslinked poly-N-[Tris(hydroxymethyl)methyl]acrylamide (PTH) network. The hydrogel can be formed , facilitating easy delivery to the GP and allowing for precise sealing of the defects. experiments, using a perforated stomach mouse model, shows that the adhesive hydrogel plug effectively seals GP defects and promotes gastric mucosa regeneration. Overall, this hydrogel represents a promising biomaterial for GP treatment.

摘要

尽管外科治疗取得了进展，但胃穿孔（GP）导致的死亡率仍然很高，最近有人提出使用粘性水凝胶作为密封和治疗胃穿孔的一种潜在选择。然而，为了有效，水凝胶必须具有足够的组织粘附性、坚韧的机械性能、可调节的生物降解性，并且理想情况下易于应用和成型。在此，我们报告一种用于密封和治疗胃穿孔的粘性弹性水凝胶。该水凝胶由生物活性的转谷氨酰胺酶（TG）交联明胶网络和动态的硼酸盐交联聚-N-[三（羟甲基）甲基]丙烯酰胺（PTH）网络组成。该水凝胶可以成型，便于输送到胃穿孔部位并精确密封缺损。使用穿孔胃小鼠模型进行的实验表明，粘性水凝胶塞有效地密封了胃穿孔缺损并促进胃黏膜再生。总体而言，这种水凝胶是一种很有前景的用于治疗胃穿孔的生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/f3761fa6306c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/52f221074c99/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/96c019e00936/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/bce12bae7768/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/980253f61862/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/35e5aceebe09/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/f3761fa6306c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/52f221074c99/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/96c019e00936/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/bce12bae7768/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/980253f61862/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/35e5aceebe09/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/8892218/f3761fa6306c/gr5.jpg

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