Cai Lijun, Zhao Cheng, Cao Xinyue, Lu Minhui, Li Ning, Luo Yuan, Wang Yongan, Zhao Yuanjin
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Bioact Mater. 2023 Sep 27;32:28-36. doi: 10.1016/j.bioactmat.2023.09.009. eCollection 2024 Feb.
Considerable efforts have been devoted to treating gastric ulcers. Attempts in this field tend to develop drug delivery systems with prolonged gastric retention time. Herein, we develop novel Chinese herb pollen-derived micromotors as active oral drug delivery system for treating gastric ulcer. Such Chinese herb pollen-derived micromotors are simply produced by asymmetrically sputtering Mg layer onto one side of pollen grains. When exposed to gastric juice, the Mg layer can react with the hydrogen ions, resulting in intensive generation of hydrogen bubbles to propel the micromotors. Benefiting from the autonomous motion and unique spiny structure, our micromotors can move actively in the stomach and adhere to the surrounding tissues. Besides, their special architecture endows the micromotors with salient capacity of drug loading and releasing. Based on these features, we have demonstrated that our Chinese herb pollen-derived micromotors could effective deliver berberine hydrochloride and show desirable curative effect on the gastric ulcer model of mice. Therefore, these Chinese herb pollen-derived micromotors are anticipated to serve as promising oral drug delivery carriers for clinical applications.
人们已经投入了大量努力来治疗胃溃疡。该领域的尝试倾向于开发具有延长胃滞留时间的药物递送系统。在此，我们开发了新型的源自中草药花粉的微马达作为治疗胃溃疡的活性口服药物递送系统。这种源自中草药花粉的微马达是通过在花粉粒的一侧不对称溅射镁层简单制备而成的。当暴露于胃液中时，镁层会与氢离子反应，从而大量产生氢气气泡以推动微马达。得益于自主运动和独特的带刺结构，我们的微马达能够在胃中主动移动并附着于周围组织。此外，它们的特殊结构赋予了微马达显著的药物负载和释放能力。基于这些特性，我们已经证明我们的源自中草药花粉的微马达能够有效递送盐酸小檗碱，并对小鼠胃溃疡模型显示出理想的治疗效果。因此，这些源自中草药花粉的微马达有望成为有前景的口服药物递送载体用于临床应用。
