van der Velden Fabian J S, van Delft Frederik, Owens Stephen, Llevadias Judit, McKean Michael, Pulford Lindsey, Taha Yusri, Williamson Grace, Campbell-Hewson Quentin, Hambleton Sophie, Payne Rebecca, Duncan Christopher, Johnston Catriona, Spegarova Jarmila, Emonts Marieke
Paediatric Immunology, Infectious Diseases and Allergy, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Front Pediatr. 2022 Mar 3;10:809061. doi: 10.3389/fped.2022.809061. eCollection 2022.
Pulmonary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children is generally described as mild, and SARS-CoV-2 infection in immunocompromised children are observed as generally mild as well. A small proportion of pediatric patients will become critically ill due to (cardio)respiratory failure and require intensive care treatment. We report the case of a teenager with Hodgkin's lymphoma who acquired SARS-CoV-2 (detected by PCR) on the day of her autologous stem cell transplant and developed acute respiratory distress syndrome, successfully treated with a combination of antivirals, immunomodulation with steroids and biologicals, and ECMO.
儿童感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）通常症状较轻，免疫功能低下的儿童感染SARS-CoV-2后症状一般也较轻。一小部分儿科患者会因（心脏）呼吸衰竭而病情危重，需要重症监护治疗。我们报告了一例青少年霍奇金淋巴瘤患者的病例，该患者在自体干细胞移植当天感染了SARS-CoV-2（通过聚合酶链反应检测到），并发展为急性呼吸窘迫综合征，通过抗病毒药物、类固醇和生物制剂进行免疫调节以及体外膜肺氧合（ECMO）联合治疗成功治愈。
